Publications by authors named "Yun-Yong Liu"
Article Synopsis
- This study focused on how patients with advanced colorectal cancer participate in treatment decisions and their perceptions of treatment effectiveness.
- Data was collected from 4,533 patients across 19 hospitals using a questionnaire that noted demographics and treatment experiences between March 2020 and March 2021.
- Findings showed that patients' involvement in decision-making varied widely, influenced by demographic factors, and that self-reported treatment efficacy decreased with subsequent treatments.
Article Synopsis
- - The study involved 1,688 Chinese patients with metastatic colorectal cancer (mCRC) across 19 hospitals to investigate the use of targeted therapies and the barriers they face in accessing these treatments.
- - About 51.6% of patients began targeted therapy, with varying rates of first-, second-, and third-line treatments; common barriers included high costs and doubts about treatment effectiveness.
- - Factors making patients less likely to start targeted therapy included older age, lower education and income levels, lack of medical insurance, and having more severe health issues; addressing cost and enhancing public education could improve treatment access.
Background: Biomarkers are a key tool in early detection, prognostication, survival, and predicting treatment response of colorectal cancer (CRC). However, little is known about biomarker testing for CRC patients in real-life clinical practice in China. This study aimed to address the usage of biomarker testing and analyze factors related to its acceptance among Chinese patients with advanced CRC.
View Article and Find Full Text PDFBackground: Colorectal cancer (CRC) causes a substantial disease burden in China. Information on the medical expenditure of CRC patients is critical for decision-makers to allocate medical resources reasonably, however, relevant data is limited in China, especially advanced CRC. The aim of this survey was to quantify the out-of-pocket medical expenditure of advanced CRC and explore associated factors.
View Article and Find Full Text PDFBackground: Colorectal cancer (CRC) poses a significant public health burden worldwide. The investigation of the choice of medical facility among CRC patients is helpful for understanding access to health services and improving quality of oncology services to optimize health outcomes. However, there are limited studies on the topic.
View Article and Find Full Text PDFBackground: Colorectal cancer (CRC) is one of the most common cancers in China, and most CRC patients have already reached an advanced stage by the time of initial diagnosis. Due to the loss of health as a result of cancer, it has consequence on the treatment which may affect the psychophysical and social impairment of CRC patients. These indicators (psychophysical, function and social impairment) affect the health-related quality of life (HRQOL).
View Article and Find Full Text PDFBackground: The imbalanced allocation of medical resources leads to the occurrence of cross-regional healthcare-seeking in China. Due to the low cure rate, advanced colorectal cancer (CRC) patients may seek cross-regional healthcare for high-level medical facilities. Investigating status of cross-regional healthcare-seeking and its associated factors among advanced CRC patients is important for policymakers to understand access to health services and improve the quality of oncology services.
View Article and Find Full Text PDFArticle Synopsis
- Colorectal cancer (CRC) is a significant health issue in China, with a growing number of cases, yet little is known about patients' awareness and knowledge of the disease.
- A nationwide survey involving 4,589 advanced CRC patients revealed that a majority lacked essential information about risk factors and screening for the disease prior to diagnosis.
- Knowledge and awareness of CRC were found to be higher among patients with better education, higher income, and different occupational backgrounds, indicating a need for targeted public education efforts.
The COmprehensive Score for financial Toxicity in China: Validation and Responsiveness.
J Pain Symptom Manage
June 2021
Context: Financial toxicity is a priority concern faced by cancer patients and oncology providers. A validated instrument is important to measure this toxicity and improve health-related quality of life of patients.
Objectives: To assess the validity and responsiveness of the Chinese version of the COmprehensive Score for financial Toxicity (COST) and to measure financial toxicity using the COST instrument in Chinese health care systems.
Article Synopsis
- This study examined the health-related quality of life (HRQoL) of colorectal precancer and cancer patients in China, using data collected from a cross-sectional survey conducted from 2012 to 2014 across 12 provinces.* -
- A total of 376 precancer and 2,470 CRC patients participated, with utility scores indicating a significant decline in HRQoL compared to the general population, particularly noting pain and discomfort as major issues.* -
- Multivariate analysis identified various factors influencing utility scores including treatment type, education, income, and geographic location, suggesting the need for tailored interventions and further evaluations in healthcare.*
Background: Most lung cancer patients are diagnosed after the onset of symptoms. However, whether the symptoms of lung cancer were independently associated with the diagnosis of lung cancer is unknown, especially in the Chinese population.
Methods: We conducted a 10 years (2005-2014) nationwide multicenter retrospective clinical epidemiology study of lung cancer patients diagnosed in China.
Background: The study was conducted to examine changes in diagnostic and staging imaging methods for lung cancer in China over a 10-year period and to determine the relationships between such changes and socioeconomic development.
Methods: This was a hospital-based, nationwide, multicenter retrospective study of primary lung cancer cases. The data were extracted from the 10-year primary lung cancer databases at eight tertiary hospitals from various geographic areas in China.
The present study aimed to investigate phosphatidylinositol 4,5-bisphosphate 3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway activation in a rat model of migraine. A total of 60 male Sprague‑Dawley rats were randomly divided into three groups: Blank control; suspension control; and migraine model. The model group was subcutaneously injected with a glyceryl trinitrate suspension, using an optimized Tassorelli method to establish a rat model of migraine.
View Article and Find Full Text PDFBackground: The present study aimed to assess the role of C3435T polymorphism in drug-resistance in epilepsy by a meta-analysis.
Material And Methods: Databases were obtained from the Cochrane Library, MEDLINE, EMBASE, PubMed, Science Direct database, CNKI, and Wanfang up to October 2014. All the case-control association studies evaluating the role of ABCB1 C3435T in pharmacoresistance to anti-epileptic drug (AED) were identified.