Publications by authors named "Yun-Ying Cheng"
The accurate and sensitive detection of biomarkers has great clinical value for the early diagnosis and treatment of cancer. Due to the excellent optical properties of carbon dots (CDs), CDs-based fluorescent detection methods have attracted increasing attention in bioanalytics. Signal reporters using CDs labeled hairpin DNA, based on Föster resonance energy transfer (FRET), have shown promise for the sensitive detection of biomarkers.
View Article and Find Full Text PDFFörster resonance energy transfer (FRET) by using fluorescent carbon dots (CDs) as energy donors shows potential for biosensing and bioimaging. However, it remains underused and underestimated for CDs as a building block for FRET owing to the low efficiency and complex operation originating from the surface modification of CDs. To overcome these limitations, herein we develop a novel FRET soft nanoball (fretSNB) in which thousands of green CDs and black hole quencher 2 (BHQ-2) dyes are loaded, and FRET occurs from CDs to BHQ-2 dyes with the consequence of effective fluorescence quenching.
View Article and Find Full Text PDFHighly sensitive colorimetric detection of silver(i) ions (Ag+) at the single-particle level was developed based on the color of a gold nanoparticle (AuNP) assembly captured by dark-field microscopy (DFM) imaging. Formation of C-Ag+-C bonding between cytosines was utilized to induce interparticle coupling of AuNPs modified with single-strand DNA, resulting in a color change as the signal transduction to quantify Ag+ under DFM imaging. This method allowed visual quantitation of Ag+ in the range of 0.
View Article and Find Full Text PDFArticle Synopsis
- Mercury ions (Hg) pose serious health risks, making their detection in herbal medicines crucial for quality control.
- A new method using fluorescent carbon dots (CDs) with a core-shell structure effectively detects Hg by forming aggregates through interaction with functional groups, leading to reduced fluorescence.
- The detection method demonstrates high sensitivity with a limit of 2.2 nM and successfully identifies Hg in complex herbal medicine samples, indicating its potential for heavy metal analysis in pharmaceuticals.
Genome-wide identification, evolution of chromobox family genes and their expression in Nile tilapia.
Comp Biochem Physiol B Biochem Mol Biol
January 2017
Article Synopsis
- Chromobox (Cbx) proteins are transcriptional repressors linked to epigenetic and developmental functions, with origins tracing back to ancient Polycomb genes in invertebrates.
- A significant expansion of the Cbx gene family has been observed in vertebrates, particularly in teleost fish, following genome duplication events.
- The study highlights the dominant expression of Cbxs in brain and gonadal tissues, suggesting their important role in the regulation of gametogenesis during development.
Article Synopsis
- - The study identified and categorized 75 nuclear receptors (NRs) in tilapia and additional NRs in various fish species, uncovering four novel NRs and exploring the effects of genome duplication on their presence in teleosts versus tetrapods.
- - Tissue expression analysis showed that 53 NRs were active in multiple tissues, while four NRs exhibited tissue-specific roles, emphasizing their importance in the brain, liver, and gonads among others.
- - The research indicated that 65 NRs were expressed in gonads with distinct timing related to sexual dimorphism, suggesting that these receptors are likely critical for sex determination and gonadal development in fish.