Improving prediction accuracy of spread through air spaces in clinical-stage T1N0 lung adenocarcinoma using computed tomography imaging models.

Objectives: To develop computed tomography (CT)-based models to increase the prediction accuracy of spread through air spaces (STAS) in clinical-stage T1N0 lung adenocarcinoma.

Methods: Three cohorts of patients with stage T1N0 lung adenocarcinoma (n = 1258) were analyzed retrospectively. Two models using radiomics and deep neural networks (DNNs) were established to predict the lung adenocarcinoma STAS status.

Changes in body weight and cardiovascular risk factors in a Chinese population with type 2 diabetes mellitus: a longitudinal study.

Introduction: The primary care management of blood glucose, blood pressure, lipid profiles, and body weight is important among patients with type 2 diabetes mellitus (T2DM) to prevent disease progression. Information on how weight changes would improve or deteriorate cardiovascular (CV) risk factors is warranted for making primary care recommendations. We aimed to investigate the changes in body weight and CV risk factors and to analyse their association in a Chinese population with T2DM.

TCR-Induced Tyrosine Phosphorylation at Tyr270 of SUMO Protease SENP1 by Lck Modulates SENP1 Enzyme Activity and Specificity.

Small ubiquitin-like modifier (SUMO) modification plays an important regulatory role in T cell receptor (TCR) signaling transduction. SUMO-specific proteases (SENPs) have dual-enzyme activities; they can both process SUMO precursors as endopeptidases and participate in SUMO deconjugation as isopeptidases. It remains unclear how the SUMO system, especially SENP1, is regulated by TCR signaling.

Risk factors for pulmonary embolism in patients with COVID-19: a systemic review and meta-analysis.

Purpose: To detect the risk factors for pulmonary embolism (PE) in patients with COVID-19.

Methods: Studies were searched for in PubMed, Cochrane Library, Web of Science, and EMBASE. Two authors independently screened articles and extracted data.

[Spatial Distribution Pattern and Influencing Factors of Industrial Pollution Emissions in Yangtze River Economic Belt].

The development of Yangtze River economic belt emphasizes the strategy of "no large-scale development, joint efforts in large-scale protection". The restoration of the Yangtze River environment has become an important part of the development of the region. Therefore, it is important to explore the spatial distribution of industrial pollution emissions and its influencing factors in the Yangtze River economic belt.

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

The nuclear pore complex (NPC) is the sole and selective gateway for nuclear transport, and its dysfunction has been associated with many diseases. The metazoan NPC subcomplex RanBP2, which consists of RanBP2 (Nup358), RanGAP1-SUMO1, and Ubc9, regulates the assembly and function of the NPC. The roles of immune signaling in regulation of NPC remain poorly understood.

Association between Systolic Blood Pressure and Diabetic Retinopathy in Both Hypertensive and Normotensive Patients with Type 2 Diabetes: Risk Factors and Healthcare Implications.

A common diabetes-related microvascular complication is diabetic retinopathy (DR), yet associations between blood pressure (BP) and risks for DR in diabetic patients with normal BP received inadequate attention. This may lead to 'clinical inertia' in early DR prevention. We aimed to assess whether the extent to which systolic BP levels were associated with DR in patients with type 2 diabetes (T2DM) and normal BP were similar to that in those with concurrent hypertension.

[Gummy smile correction by intruding upper incisors with mini-screw implant: an esthetic evaluation by the golden facial mask].

Objective: to use a golden facial mask to classify the gummy smile and then to evaluate the effectiveness of correction gummy smile by intruding upper incisors and canines with mini-screw implants.

Methods: sixteen female and 1 male gummy smile patients with an age range of 16 - 40 years, 26.2 years on average, were involved in the study.

[Intruding upper incisors using mini-screw anchorage in patients with gummy smile].

Objective: To evaluate the effectiveness of mini-screw anchorage on intruding upper incisors in patients with gummy smile.

Methods: Sixteen female patients (mean age: 23.8 years) were involved in this study.

[An experimental study on injury of hippocampus neurons in rats by simulated push-pull maneuver of different degrees].

Objective: To explore the degree of injury and phase of push-pull effect induced by different degrees of push-pull maneuver on hippocampus neurons in rats.

Method: Injury of push-pull maneuver on hippocampus neurons in rats after different degrees of push-pull maneuver were determined by general evaluation of animal model, pathologic examination and electronic microscopy.

Result: 1) General evaluation of animal model: the apoplexy index and the pathological grading increased with the increase of intensity of the push-pull maneuver.

[Effect of push-pull maneuver on distribution of DNA and NO content in rats' brain tissue].

Objective: To study the effect of push-pull maneuver on cerebral apoptosis and NO content of rats.

Method: Ninety male Wistar rats were randomly divided into the control group, +Gz exposure group and the push-pull maneuver group. The rats were killed after 30 min exposure, 3 h, 12 h, 24 h or 48 h exposure, and the brain tissues were taken.