Publications by authors named "Yun-Xing Cao"
Article Synopsis
- - Hereditary protein C deficiency is a genetic disorder linked to mutations in the protein C gene, primarily in exons 4-9 and intron 8, and can lead to serious conditions like venous thrombosis.
- - Fatal pulmonary embolism resulting from protein C gene mutations is uncommon, and treating it presents significant challenges.
- - The article highlights a case where a frameshift mutation in exon 8 led to fatal pulmonary embolism, and it discusses a successful treatment approach using extracorporeal membrane oxygenation with interventional thrombectomy, offering insights for future diagnoses and treatments.
Background And Purpose: The need for dose adjustment of caspofungin in patients with hepatic impairment is controversial, especially for those with Child-Pugh B or C cirrhosis. The purpose of this study was to investigate the safety and efficacy of standard-dose caspofungin administration in Child-Pugh B and C cirrhotic patients in a real-world clinical setting.
Patients And Methods: The electronic medical records of 258 cirrhotic patients, including 67 Child-Pugh B patients and 191 Child-Pugh C patients, who were treated with standard-dose of caspofungin at the Second Affiliated Hospital of Chongqing Medical University, China, from March 2018 to June 2023 were reviewed retrospectively.
The liver is vulnerable to sepsis, and sepsis-induced liver injury is closely associated with poor survival of sepsis patients. Studies have found that the overproduction of reactive oxygen species (ROS) is the major cause of oxidative stress, which is the main pathogenic factor for the progression of septic liver injury. The mitochondria are a major source of ROS.
View Article and Find Full Text PDFMorphological characteristics associated with rupture risk of multiple intracranial aneurysms.
Asian Pac J Trop Med
October 2017
Article Synopsis
- The study aimed to find out which characteristics of intracranial aneurysms (IAs) are linked to their rupture using data from 107 patients.
- Key features analyzed included location, shape, size, and ratios related to the blood vessel's dimensions, assessed through CT angiography.
- The findings indicated that IAs in the internal carotid artery have a lower risk of rupture, while high aspect ratios and certain size ratios increase the risk of rupture in multiple IAs.
Objective: To establish an animal model to replicate the blunt impact brain injury in forensic medicine.
Methods: Twenty-four New Zealand white rabbits were randomly divided into control group (n equal to 4), minor injury group (n equal to 10) and severe injury group (n equal to 10). Based on the BIM-II Horizontal Bio-impact Machine, self-designed iron bar was used to produce blunt brain injury.