Gut microbiota shed new light on the management of immune-related adverse events.

Immunotherapy has dramatically revolutionized the therapeutic landscape for patients with cancer. Although immune checkpoint inhibitors are now accepted as effective anticancer therapies, they introduce a novel class of toxicity, termed immune-related adverse events, which can lead to the temporary or permanent discontinuation of immunotherapy and life-threatening tumor progression. Therefore, the effective prevention and treatment of immune-related adverse events is a clinical imperative to maximize the utility of immunotherapies.

Intrathecally administered pizotifen alleviates neuropathic and inflammatory pain in mice by enhancing GABAergic inhibition.

Chronic pain, such as chronic neuropathic pain and chronic inflammatory pain, is often difficult to manage and bring great trouble to patients. 5-HT plays a key role in the process of pain transmission both in centrally and peripherally. Tricyclic antidepressants (TCA) such as amitriptyline are classical 5-HT reuptake inhibitors, are recommended as the first-line treatment for chronic pain.

[Frequency up-conversion properties of Er3+ /Yb3+ co-doped zinc oxide powders].

Er3+ /Yb3+ co-doped ZnO powders were prepared by the high temperature sintering method with starting composition of (mol%) 95ZnF2-4. 8Yb2 O3-0. 2Er2 O3.

[Spectroscopic properties of Er3+-doped germanium bismuthate glass].

Er(3+)-Doped Germanium Bismuthate Glass was fabricated and characterized. The absorption spectrum and up-conversion spectrum of glass were studied. The Judd-Oflet intensity parameters omega(t) (t = 2, 4, 6), determined based on Judd-Ofelt theory, were found to be omega2 = 3.