Publications by authors named "Yun-Xiang Yang"
Article Synopsis
- The glycan loop of the Zika virus (ZIKV) envelope protein is crucial for the virus's harmful effects and transmission; recent studies showed that deletions in this loop have returned in modern Asian strains.
- Researchers created ZIKV variants with these deletions, finding that while they had reduced effects in adult mouse models and less transmission in mosquitoes, they surprisingly caused more severe brain issues in newborn mice.
- This research highlights the role of glycan loop deletions in increasing ZIKV neurovirulence, emphasizing the need for more global virology studies on the virus's evolution and its implications.
