Publications by authors named "Yun-Xiang Sun"
Surfactin inhibits Fusarium graminearum by accumulating intracellular ROS and inducing apoptosis mechanisms.
World J Microbiol Biotechnol
October 2023
Fusarium graminearum, a devastating fungal pathogen, is the main pathogen of Fusarium head blight (FHB) in wheat globally; it results in significant yield loss and mycotoxin contamination that severely threatens global wheat production and food safety. However, despite ongoing efforts, controlling this pathogen still remains a major challenge. Surfactin, primarily synthesized by Bacillus sp.
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- - Sirtuin 6 (SIRT6) is involved in around 20% of all cancers, including colon and rectal cancers, but no effective drugs currently target it.
- - Researchers are investigating small natural compounds, particularly Scutellarin from Huang Qin, to find potential SIRT6 inhibitors through molecular dynamics simulations.
- - The study reveals that certain small molecule inhibitors, including Scutellarin, interact with SIRT6 in a similar way, highlighting the importance of hydrophobic and π-stacking interactions in their binding.