Publications by authors named "Yun-Xi Cai"
In this study, we redefine the diagnostic landscape of diabetic ulcers (DUs), a major diabetes complication. Our research uncovers new biomarkers linked to immunogenic cell death (ICD) in DUs by utilizing RNA-sequencing data of Gene Expression Omnibus (GEO) analysis combined with a comprehensive database interrogation. Employing a random forest algorithm, we have developed a diagnostic model that demonstrates improved accuracy in distinguishing DUs from normal tissue, with satisfactory results from ROC analysis.
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- Chromosomal copy number aberrations (CNAs) are significant markers in bladder cancer, and this study aimed to develop a low-coverage whole-genome sequencing method to detect CNAs in urine samples from patients.
- The study involved urine sediment from 65 patients, allowing for comparison of CNAs between those with bladder cancer, benign tumors, and healthy controls, resulting in a notable detection rate in cancer patients.
- The findings revealed specific chromosomal regions affected by CNAs in bladder cancer, showcasing the method's potential for noninvasive diagnosis, although further validation is needed.