Publications by authors named "Yun-Tian Guo"
BMC Infect Dis
December 2023
Article Synopsis
- Antiretroviral therapy (ART) effectively lowers viral loads in HIV-infected individuals, but some still experience poor immune recovery; researchers studied the immune cell profiles to understand this phenomenon better.
- The study analyzed immune cells from different groups (treatment-naïve, immunological non-responders, immunological responders, and healthy controls) using mass cytometry and identified correlations between immune cell types and various health indicators like viral RNA and CD4 counts.
- Key findings included observed immune cell activation, exhaustion, and changes in specific immune cell subsets among treatment-naïve individuals, indicating a relationship between immune cell composition and the success of ART, which may help tackle incomplete immune recovery in certain patients.
Article Synopsis
- The intestinal epithelial barrier is crucial in the progression of HIV disease, but its damage in different patient groups is not well understood.
- A study compared intestinal damage and related markers among immunological responders (IRs), immunological non-responders (INRs), and healthy controls.
- It found that both IRs and INRs had persistent intestinal damage, with INRs showing more severe damage, which was linked to higher HIV DNA levels and lower CD4 T cell counts.
Article Synopsis
- Studies on gut immune balance in HIV patients are limited; this research focuses on intestinal samples from different groups: immunological nonresponders (INRs), immunological responders (IRs), and HIV-negative controls.
- Key findings reveal that INRs have reduced Th17 and increased Treg cell counts compared to IRs, highlighting a significant difference in the Th17/Treg ratio, which is linked to markers of intestinal health like ZO-1 and I-FABP.
- The Th17/Treg ratio correlates positively with CD4 T cell counts and negatively with intestinal HIV DNA, suggesting that an imbalance in these cells indicates incomplete immune recovery and is associated with intestinal damage in HIV-infected individuals.
Article Synopsis
- The study aimed to investigate how serum globulin levels relate to immune restoration and the size of the HIV reservoir in patients on long-term antiretroviral therapy (ART).
- Researchers monitored 13 HIV patients on ART for 5 years, measuring various markers including serum globulin, HIV DNA, and T-cell activation indicators at multiple time points.
- Results indicated that higher serum globulin levels were linked to larger HIV reservoirs and more activated T-cells, suggesting a potential role of serum globulin in immune response and control of HIV during extended ART.
Article Synopsis
- The study aimed to analyze β7 CD4 T cells in HIV-1 infected patients to understand their role in disease progression.
- The research included 124 HIV-1 patients and healthy controls, assessing β7 CD4 T cell characteristics using flow cytometry and other techniques.
- Results showed a decrease in β7 CD4 T cell frequency correlated with worsening disease, with these cells being more susceptible to HIV-1 infection and associated with a Th17 phenotype.
