Publications by authors named "Yun-Suk Yu"
Article Synopsis
- Triple-negative breast cancer (TNBC) has a worse prognosis than other breast cancer types and lacks reliable biomarkers to predict patient outcomes.
- This study analyzed gene expressions from 184 TNBC patient samples using RNA sequencing, identifying a 10-gene signature that accurately predicts invasive disease-free survival.
- The 10-gene signature shows strong sensitivity and specificity, and it may enhance personalized treatment approaches for TNBC patients by serving as a novel prognostic biomarker.
Intrahepatic mononuclear phagocytes (MPs) are critical for the initiation and progression of liver fibrosis. In this study, using multiplexed digital spatial protein profiling, we aimed to derive a unique protein signature predicting advanced liver fibrosis. Snap-frozen liver tissues from various chronic liver diseases were subjected to spatially defined protein-based multiplexed profiling (Nanostring GeoMX).
View Article and Find Full Text PDFInnate and adaptive immune responses are critically associated with the progression of fibrosis in chronic liver diseases. In this study, we aim to identify a unique immune-related gene signature representing advanced liver fibrosis and to reveal potential therapeutic targets. Seventy-seven snap-frozen liver tissues with various chronic liver diseases at different fibrosis stages (1: = 12, 2: = 12, 3: = 25, 4: = 28) were subjected to expression analyses.
View Article and Find Full Text PDFBackground/aim: Uniform treatment of hepatocellular carcinoma (HCC) with molecular targeted drugs (e.g., sorafenib) results in a poor overall tumor response when tumor subtyping is absent.
View Article and Find Full Text PDFPreoperative chemoradiotherapy (PCRT) and subsequent surgery is the standard multimodal treatment for locally advanced rectal cancer (LARC), albeit PCRT response varies among the individuals. This creates a dire necessity to identify a predictive model to forecast treatment response outcomes and identify patients who would benefit from PCRT. In this study, we performed a gene expression study using formalin-fixed paraffin-embedded (FFPE) tumor biopsy samples from 156 LARC patients (training cohort = 60; validation cohort = 96); we identified the nine-gene signature (, , , , , , , , and ) that distinctively differentiated responders from non-responders in the training cohort (accuracy = 86.
View Article and Find Full Text PDFPurpose: OncoHepa test is a multigene expression profile test developed for assessment of hepatocellular carcinoma (HCC) prognosis. Multiplication of α-FP, des-γ-carboxy prothrombin (DCP) and tumor volume (TV) gives the α-FP-DCP-volume (ADV) score, which is also developed for assessment of HCC prognosis.
Methods: The predictive powers of OncoHepa test and ADV score were validated in 35 patients who underwent curative hepatic resection for naïve solitary HCCs ≤5 cm.
Article Synopsis
- The study investigates the impact of transcatheter arterial chemoembolization (TACE) on hepatocellular carcinoma (HCC) patients, focusing on the role of hypoxia-inducible factor 1α (HIF-1α) in prognosis after treatment.
- A retrospective analysis of 35 HCC patients revealed that preoperative TACE was linked to a higher 2-year recurrence rate and shorter disease-free survival period.
- The research highlights that TACE activates HIF-1α, leading to poor outcomes in HCC patients, suggesting HIF-1α's significant prognostic relevance post-treatment.
Background: The effectiveness of molecular targeted agents is modest in hepatocellular carcinoma (HCC). Efficacy of molecular targeted therapies has been better in cancer patients with high expression of actionable molecules defined as cognate target molecules. However, patient stratification based on the actionable molecules dictating the effectiveness of targeted drugs has remained understudied in HCC.
View Article and Find Full Text PDFHepatocellular carcinoma is one of the most lethal cancers worldwide. More accurate stratification of patients at risk is necessary to improve its clinical management. As epithelial-mesenchymal transition is critical for the invasiveness and metastasis of human cancers, we investigated expression profiles of 12 genes related to epithelial-mesenchymal transition through a real-time polymerase chain reaction.
View Article and Find Full Text PDFBackground: Hepatocellular carcinoma (HCC) is the most common tumor in the adult liver, with high relapse and mortality rates despite diverse treatment modalities. In this study, nicotinamide N-methyltransferase (NNMT), a key enzyme in drug metabolism, was investigated as a potential prognostic factor.
Methods: Frozen tumors and non-cancerous surrounding tissues from 120 patients with primary HCC were studied.