Publications by authors named "Yun-Rui Li"
Herein, by directly introducing mismatched reactant DNA, high-reactivity and high-threshold enzyme-free target recycling amplification (EFTRA) is explored. The developed high-efficiency EFTRA (HEEFTRA) was applied as a programmable DNA signal converter, possessing higher conversion efficiency than the traditional one with perfect complement owing to the more negative reaction standard free energy (Δ). Once traces of input target miRNA interact with the mismatched reactant DNA, amounts of ferrocene (Fc)-labeled output DNA could be converted the EFTRA.
View Article and Find Full Text PDFmiR-485-5p suppresses breast cancer progression and chemosensitivity by targeting survivin.
Biochem Biophys Res Commun
June 2018
Article Synopsis
- - Breast cancer is the most prevalent cancer among women globally, and a major challenge in treatment is chemoresistance linked to microRNA (miRNA) dysregulation.
- - The study highlights miR-485-5p as a promising tumor suppressor that, when overexpressed, can slow down breast cancer growth and improve the effectiveness of chemotherapy in lab and animal models.
- - It was found that miR-485-5p targets the survivin gene, and high levels of survivin can counteract the beneficial effects of miR-485-5p, suggesting that manipulating this pathway could improve chemotherapy responses in breast cancer patients.
Background: Breast cancer is the most common cancer among women worldwide and metastasis is the leading cause of death among patients with breast cancer. The transforming growth factor-β (TGF-β) pathway plays critical roles during breast cancer epithelial-mesenchymal transition (EMT) and metastasis. SMAD2, a positive regulator of TGF-β signaling, promotes breast cancer metastasis through induction of EMT.
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