Publications by authors named "Yun-Rui Cai"
Article Synopsis
- Coumestans are important chemical structures found in various natural products, and creating derivatives can help in finding new medicinal compounds.
- This research developed a scalable method to synthesize 8,9-dihydroxycoumestans using a specialized two-electrode electrolysis technique, protecting sensitive intermediates during the process.
- A study on these compounds found that one derivative, compound 3 r, has strong antiproliferative effects and inhibits topoisomerase I, suggesting it could be a promising lead for new cancer treatments.
The production of bioactive pharmaceutical ingredients in a sustainable manner has become essential in the modern academic and industrial community. Herein, we report a chemically robust and sustainable aerobic oxidation for the synthesis of the phenothiazinone framework, using the commercially available TEMPO/HBF/NaNO co-catalytic system under an ambient atmosphere. The reaction is highly efficient with broad scopes and excellent scalability.
View Article and Find Full Text PDFPhenothiazinone is a promising yet underutilized fluorophore, possibly due to the lack of a general accessibility. This study reports a robust and scalable TEMPO-mediated electrochemical method to access a variety of phenothiazinones from 2-aminothiophenols and quinones. The electrosynthesis proceeds in a simple cell architecture under mild condition, and notably carbon-halogen bond in quinones remains compared to conventional methods, enabling orthogonal downstream functionalization.
View Article and Find Full Text PDF