Publications by authors named "Yun-Qi Zhang"
Article Synopsis
- Breast cancer poses a significant health risk to women, highlighting the need for more effective treatment options; researchers are exploring the inhibition of glucose metabolism as a potential strategy.
- The newly identified GAPDH inhibitor, DC-5163, was tested for its ability to hinder breast cancer cell growth both in lab settings and in mouse models, focusing on its effects on cellular energy processes.
- Results showed that DC-5163 effectively reduced the energy supply of cancer cells, led to cell cycle arrest, increased apoptosis, and significantly suppressed tumor growth in animal models without causing major side effects.
Article Synopsis
- International migration has contributed to the global spread of HIV-1, with subtypes A and G primarily found in Africa but rarely in China; a case of imported recombinant HIV-1 was identified in a Chinese female.
- Genetic analysis revealed that this recombinant virus contains segments from sub-subtypes A1 and A7, as well as subtype G, with a history of exposure linked to a partner from Nigeria.
- The findings underscore the importance of genome sequencing for tracking HIV-1 evolution and the need for ongoing monitoring of infections in international migrants.
Objective: To investigate the molecular epidemiology of HIV-1 in Heilongjiang, China, and try to spot signs of new circulating recombinant form (CRF) in this region.
Design: A molecular epidemiological study was conducted in Heilongjiang, China during 2011-2020.
Methods: Plasma samples were collected from three HIV-1-positive patients (two MSM and one man lacking risk factor information).
In this study, we investigated the effect of neuregulin-1 (NRG1) on demyelination and neurological function in an ischemic stroke model, and further explored its neuroprotective mechanisms. Adult male ICR mice underwent photothrombotic ischemia surgery and were injected with NRG1 beginning 30 min after ischemia. Cylinder and grid walking tests were performed to evaluate the forepaw function.
View Article and Find Full Text PDFBackground: Human immunodeficiency virus type 1 (HIV-1) epidemic in China is featured by geographical diversity of epidemic patterns. Understanding the characteristics of regional HIV-1 epidemic allows carrying out targeted prevention and controlling measures. This seven-year cross-sectional study was conducted in Heilongjiang, one province of Northeast China, where newly diagnosed infection is fast increasing yearly, but temporal HIV-1 epidemic trend is largely unknown.
View Article and Find Full Text PDFBackground: To investigate the reference value of blood gas analysis and related factors in healthy adults in Diqing Tibetan Autonomous Prefecture in Yunnan Province.
Methods: From August 24, 2018 to August 11, 2020, healthy people between the ages of 18 and 70 years were observed at the Physical Examination Center of People's Hospital of Diqing Tibetan Autonomous Prefecture in Yunnan province. Participant information and clinical characteristics were collected.
[Glycyrrhetinic acid selectively inhibits proliferation of hepatocellular carcinoma cells in vitro].
Nan Fang Yi Ke Da Xue Xue Bao
April 2018
Objective: To investigate the selective inhibitory effect of glycyrrhetinic acid on 4 hepatocellular carcinoma (HCC) cells with different proliferation rates and explore the underlying mechanisms.
Methods: MTT method was used to detect the proliferation rates of 4 HCC cell lines, namely SMMC-7721, SK-HEP1, HEPG2 and HEP3B. Following treatment of the cells with glycyrrhetinic acid (5, 10, 20, 30, 40, and 60 µmol/L), the cell viability was analyzed using MTT assay and the expressions of total ERK protein, p-ERK protein and topoisomerase IIα were detected using Western blotting.
Small cell lung cancer (SCLC) remains one of the most aggressive tumors with a poor prognosis. The clinical outcome of SCLC patients has reached its plateau with the existing standard treatment and thus new therapies are urgently required. Accumulating evidences have indicated that doxycycline, a commonly used antibiotic, has antitumor activity against several malignancies.
View Article and Find Full Text PDF[Level of alpha-granule membrane protein (CD62P) in coronary heart disease].
Zhonghua Yi Xue Za Zhi
January 2008
Objective: To investigate the role of alpha-granule membrane protein (CD62P), marker of plate activation, in the patients with coronary heart disease (CHD) and to investigate the relationship between the severity of coronary artery stenosis and platelet activation.
Methods: Peripheral blood samples were collected from 70 patients with CHD, including 28 cases of stable angina pectoris (SAP), 26 cases of unstable angina pectoris (UAP), and 16 cases of acute myocardial infarction (AMI), all of which underwent coronary arteriography, and 20 angiographically normal persons as no-CHD controls. The CD62P level was analyzed by flow cytometry (FCM).