Publications by authors named "Yun-Min Yi"
Article Synopsis
- The study aimed to compare the effects of high vs low concentrations of hyaluronic acid eye drops on dry eye syndromes (DES) through randomized controlled trials (RCTs).
- A total of 10 RCTs with 1,796 participants were analyzed, revealing that high-concentration hyaluronic acid significantly improved corneal fluorescein staining scores, but other metrics like Schirmer's test and tear breakup time showed no significant differences.
- The conclusion suggests that while high-concentration hyaluronic acid is beneficial for dry eyes with corneal staining, it doesn't provide substantial benefits in other dry eye conditions compared to lower concentrations.
Drp1-dependent mitochondrial fission mediates corneal injury induced by alkali burn.
Free Radic Biol Med
November 2021
Corneal alkali burn, one of the most serious ophthalmic emergencies, is difficult to be cured by conservative treatments. It is well known that oxidative stress, inflammation and neovascularization are the main causes of corneal damage after alkali burn, but its underlying mechanism remains to be elucidated. Here, we reported that the expression and phosphorylation (Ser616) of mitochondrial fission protein Drp1 were up-regulated at day 3 after alkali burn, while mitochondrial fusion protein Mfn2 was down-regulated.
View Article and Find Full Text PDFThe protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice.
Int J Ophthalmol
November 2015
Aim: To determine the effect of different concentrations of the acetylcholinesterase (AChE) inhibitors tacrine and donepezil on retinal protection in AChE(+/-) mice (AChE knockout mice) of various ages.
Methods: Cultured ARPE-19 cells were treated with hydrogen peroxide (H2O2) at concentrations of 0, 250, 500, 1000 and 2000 µmol/L and protein levels were measured using Western blot. Intraperitoneal injections of tacrine and donepezil (0.