Clinical manifestations and pathogenesis of mitochondrial dysfunction in short stature.

Background: Mitochondria plays a pivotal role in cellular energy production, and their dysfunction can lead to a spectrum of mitochondrial diseases, affecting various organs with a wide range of clinical symptoms. Among these, short stature is a notable manifestation, yet its pathogenesis related to mitochondrial dysfunction remains underexplored.

Data Sources: A comprehensive literature search was conducted in the PubMed, Medline, and EMBASE databases from inception to November 2024.