In this paper, microwave-assisted (MW-AE), enzyme-assisted (Ene-AE) and microwaving plus enzymatic treatment (MW + Ene-AE) were used to explored their effects on the polyphenols in safflower seeds and safflower seed oil (SSO). The results showed that the introduction of MW-AE treatment prior to Ene-AE enhanced enzyme accessibility, resulting in MW + Ene-AE achieving the highest efficiency for polyphenol extraction from seeds, with a 67 % improvement compared to the control sample. Different treatments significantly altered the composition of polyphenols in the seeds, with a noticeable conversion of polyphenol glycosides to aglycones observed in Ene-AE and MW + Ene-AE.
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