[The effects of microgravity on blood vessels and vascular endothelial cells].

The dysfunction of vascular system is one of the main causes of orthostatic intolerance induced by microgravity. Vascular endothelial cell is a single layer on the inner wall of the blood vessel and is the important component of the blood vessel wall. Vascular endothelial cell plays a pivotal role in the regulation of vascular functions, such as serving as a permeability barrier, regulating vasoconstriction and vasodilatation.

Risk/benefit profile of panitumumab-based therapy in patients with metastatic colorectal cancer: evidence from five randomized controlled trials.

This study aims to evaluate the risk and benefit profiles of panitumumab-based therapy (PBT) in patients with metastatic colorectal cancer (mCRC). Relevant randomized controlled trials were identified by searching PubMed, Medline, EMBASE and Cochrane Library. Data on progression-free survival (PFS), overall survival (OS), all grade and severe (grade ≥3) adverse events were extracted and pooled to calculate hazard ratios (HRs) and risk ratios (RRs) with 95 % confidence intervals (CIs).

[Forensic evidence-based medicine in computer communication networks].

As an important component of judicial expertise, forensic science is broad and highly specialized. With development of network technology, increasement of information resources, and improvement of people's legal consciousness, forensic scientists encounter many new problems, and have been required to meet higher evidentiary standards in litigation. In view of this, evidence-based concept should be established in forensic medicine.

[The disruptive effect of N'N-methylene-bis on the function of FRTL-5 cells].

Objective: To study the impact of N' N-methylene-bis on thyroglobulin produced by FRTL-5 cells, and to explore the potential of using FRTL-5 cells to screen environmental thyroid hormone disruptors in vitro.

Methods: The FRTL-5 cells were treated with 0.1, 1.

Tea consumption and risk of endometrial cancer: a metaanalysis.

Objective: The objective of the study was to assess the association between tea consumption and endometrial cancer.

Study Design: Studies were identified by searching PubMed and EMBASE databases and screening the references of retrieved articles. The summary relative risk (RR) with 95% confidence interval (CI) was calculated.

[Adverse effects of nonylphenol on the reproductive development of F1 male SD rats in sexual maturation period].

Objective: To investigate the adverse effects of perinatal exposure to nonylphenol (NP) on the reproductive development of F1 male SD rats in sexual maturation period.

Methods: The pregnant rats were randomly divided into control, 50 mg/kg, 100 mg/kg, and 200 mg/kg NP groups respectively. NP was administered to dams by gavage from gestation day 7 to weaning period.