Publications by authors named "Yun-Hong Zhan"
Article Synopsis
- Renal cell carcinoma (RCC) is the deadliest urological cancer, with tumor angiogenesis playing a key role in its growth and spread.
- Epidermal growth factor-like domain multiple 7 (EGFL7) is often overexpressed in various cancers and linked to poor outcomes, but its specific role in RCC was unclear until this study.
- The research indicated that lower EGFL7 levels reduced RCC cell migration and tubule formation, decreased focal adhesion kinase (FAK) phosphorylation, and resulted in smaller tumors with lower vascular density, highlighting EGFL7's critical role in angiogenesis for RCC growth.
Background: Renal-cell carcinoma (RCC) is resistant to almost all chemotherapeutics and radiation therapy. β-Elemene, a promising anticancer drug extracted from a traditional Chinese medicine, has been shown to be effective against various tumors. In the present study, anti-tumor effects on RCC cells and the involved mechanisms were investigated.
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