Publications by authors named "Yun-Hao Zhou"
Article Synopsis
- Poncirin, a natural flavonone from Poncirus trifoliata, shows promise as a treatment for HER2 overexpressing breast cancer, a common type of cancer affecting over 20% of cases.* -
- The study employed various experimental techniques, including cell proliferation and migration assays, to evaluate Poncirin's effects and explored its interactions with the PI3K/AKT signaling pathway.* -
- Results indicate that Poncirin effectively inhibits the growth and spread of HER2 overexpressing breast cancer cells, suggesting it could be a valuable therapeutic agent in managing this disease.*
CDK11 is an emerging druggable target for cancer therapy due to its prevalent roles in phosphorylating critical transcription and splicing factors and in facilitating cell cycle progression in cancer cells. Like other cyclin-dependent kinases, CDK11 requires its cognate cyclin, cyclin L1 or cyclin L2, for activation. However, little is known about how CDK11 activities might be modulated by other regulators.
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