Comprehensive analysis of the correlation between GSTM1 and tumor immunity in colon cancer.

Background: Glutathione S-transferase mu 1 () is one of the major glutathione conjugation enzymes. Its expression and activity have been suggested to correlate with the occurrence of colon cancer; however, the role of in tumor immunity remains unclear.

Methods: Relevant data downloaded from The Cancer Genome Atlas (TCGA), Clinical Proteomic Tumor Analysis Consortium (CPTAC), and Human Protein Atlas (HPA) was used to perform a multi-dimensional expression analysis of in colon adenocarcinoma (COAD).

An updated meta-analysis of transanal drainage tube for prevention of anastomotic leak in anterior resection for rectal cancer.

Background: Anastomotic leakage (AL) is one of the most serious complications after anterior resection for rectal cancer. Transanal drainage tube (TDT) placement is widely used to reduce AL, but its efficacy remains controversial. We performed a meta-analysis to evaluate the effectiveness of TDT for prevention of AL, using updated evidence.

MicroRNA-194 modulates epithelial-mesenchymal transition in human colorectal cancer metastasis.

MicroRNAs (miRNAs), as key regulators of gene expression, are closely related to tumor occurrence and progression. MiR-194 has been proved as a tumor regulatory factor in various cancers; however, the biological function and mechanism of action in colorectal cancer (CRC) have not been well explored. In the present study, we found that miR-194 expression is upregulated in CRC clinical specimens, while overexpression of miR-194 promotes cell migration and invasion in CRC cell lines.

Portal hemodynamics before and after liver resection and its correlation with post-hepatectomy liver failure in patients with Child-Pugh class A: analysis of 151 consecutive cases.

Background/aims: Low portal velocity (PV) was found in cirrhotic patients, which was thought to be a risk factor for post-hepatectomy liver failure (PHLF). This study attempted to find out whether a correlation existed between portal hemodynamics and PHLF.

Methodology: From December 2010 to December 2012, all consecutive patients with Child-Pugh class A underwent liver resection were included.

Anatomic versus non-anatomic liver resection for hepatocellular carcinoma: a systematic review.

Background/aims: To evaluate the feasibility and therapeutic effects of anatomic liver resection versus non-anatomic liver resection for hepatocellular carcinoma.

Methodology: Randomized controlled trials and non-randomized trials comparing the clinical effectiveness between anatomic and non-anatomic liver resection for hepatocellular carcinoma were identified by using a predefined search strategy. A meta-analysis was performed to estimate pooled survival and recurrence rate.

Influence of clinically significant portal hypertension on hepatectomy for hepatocellular carcinoma: a meta-analysis.

Background: Clinically significant portal hypertension (PHT) is considered as a contraindication for hepatectomy according to the guidelines of the European Association for Study of Liver and the American Association for Study of Liver Diseases. However, this issue remains controversial. Here we performed a meta- analysis to evaluate the impact of PHT on the results of hepatectomy for hepatocellular carcinoma (HCC).

Resection margin in hepatectomy for hepatocellular carcinoma: a systematic review.

Background/aims: To evaluate the influence of the width of resection margin on recurrence and survival for hepatocellular carcinoma.

Methodology: Randomized controlled trials and non-randomized trials evaluating the influence of the width of resection margin for HCC were identified using a predefined search strategy. A meta-analysis was performed to estimate pooled recurrence and survival rate.