Publications by authors named "Yun-Chun Zhao"
Article Synopsis
- Methotrexate (MTX) is an effective drug for inflammatory and autoimmune diseases, but its use through the skin is limited because it doesn't penetrate well.
- Researchers created MTX-loaded micelles using a cationic material called DMSAP to improve its delivery and reduce side effects.
- The study found that these micelles can effectively penetrate the skin and deliver MTX more efficiently than the drug in its free form, suggesting they could be a useful treatment method for skin diseases.
A novel cationic cholesterol derivative-based small interfering RNA (siRNA) interference strategy was suggested to inhibit Notch1 activation in SKOV3 cells for the gene therapy of ovarian cancer. The cationic cholesterol derivative, -(cholesterylhemisuccinoyl-amino-3-propyl)-, -dimethylamine (DMAPA-chems) liposome, was incubated with siRNA at different nitrogen-to-phosphate ratios to form stabilized, near-spherical siRNA/DMAPA-chems nanoparticles with sizes of 100-200 nm and zeta potentials of 40-50 mV. The siRNA/DMAPA-chems nanoparticles protected siRNA from nuclease degradation in 25% fetal bovine serum.
View Article and Find Full Text PDF