Publications by authors named "Yun-Chang Liu"
Article Synopsis
- The study investigates the efficacy and safety of molecular-targeted agents for treating recurrent or metastatic adenoid cystic carcinoma (R/M ACC), as there is no consensus on their effectiveness.
- A systematic review included 28 studies with 849 patients, analyzing key outcomes like the objective response rate (ORR) and progression-free survival (PFS), highlighting that multiple kinase inhibitors (MKIs) show improved results compared to other targeted therapies.
- The study found a low pooled ORR of 4.0% but a high disease control rate (DCR) of 80.5%, and identified fatigue, hypertension, and nausea as the most common adverse effects, suggesting potential benefits of combining MKIs with immune checkpoint inhibitors for better
Purpose/objective(s): To establish the distribution pattern of cervical lymph node metastasis (LNM) and propose optimized clinical target volume (CTV) boundaries specific to oral/ oropharyngeal squamous cell cancer (OSCC/OPSCC).
Materials/methods: 531 patients with pathologically confirmed OSCC/OPSCC were enrolled from January 2013 to June 2022. Patients were stratified into two groups based on the minimal distance from the lesion's edge to the body's midline: ≤1 cm or > 1 cm.
Background And Purpose: We investigated the dynamics of eosinophil depletion during definitive concurrent chemo-radiotherapy (CCRT) and their association with the prognosis of stage Ⅱ-Ⅳa nasopharyngeal carcinoma (NPC) patients.
Materials And Methods: Fuzzy C-means algorithm (FCMA) assessed longitudinal trends in circulating eosinophil counts (CECs) of 1225 patients throughout the period of radical radiotherapy. The prognostic impact on patients' survival was evaluated with Kaplan-Meier analysis and Cox proportional risk model was used to determine the hazard ratio for adverse prognostic effects in grades of eosinophil depletion.
Background: Despite its effectiveness, the standard course of chemoradiation for the treatment of human papillomavirus (HPV)-related oropharyngeal carcinoma (OPC) results in considerable treatment-related adverse effects. Studies proved that HPV-positive OPC is very sensitive to radiotherapy. Using de-escalation therapy as a new strategy is critical to maintaining positive outcomes while alleviating side effects.
View Article and Find Full Text PDFBackground And Purpose: Radiotherapy (RT) is a double-edged sword in regulating immune responses. This study aimed to investigate the impact of thoracic RT on circulating eosinophils and its association with patient outcomes in non-small cell lung cancer (NSCLC).
Materials And Methods: This retrospective study included 240 patients with advanced NSCLC treated with definitive thoracic RT from January 2012 to January 2020.