Publications by authors named "Yun-Chan Tsai"
The global rise of multidrug-resistant strains, especially those that are resistant to carbapenems and produce metallo-β-lactamases, poses a critical challenge in clinical settings owing to limited treatment options. While bacteriophages show promise in treating these infections, their use is hindered by scarce resources and insufficient genomic data. In this study, we isolated ECLFM1, a novel phage, from sewage water using a carbapenem-resistant clinical strain as the host.
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- Acinetobacter baumannii is a drug-resistant pathogen that often causes hospital infections, making it hard to treat.
- Researchers are exploring the use of temperate phages, like the newly characterized vB_AbaM_ABMM1 (ABMM1), as an alternative to antibiotics, which has been less studied than their lytic counterparts.
- The ABMM1 phage shows promising antibacterial properties, including rapid adsorption and stability, and its genomic analysis suggests it has no antibiotic-resistance genes, indicating potential as a treatment for A. baumannii infections.