Publications by authors named "Yun-A Jo"

Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) play important roles in coagulation. The aim of this study was to investigate the distributions of TF and TFPI polymorphisms in Koreans and to analyze the association of these genetic polymorphisms with plasma levels and development of venous thromboembolism (VTE). The polymorphisms TF 5466 A > G, TF -603 A > G, TFPI -287 T > C and TFPI -33 T > C were investigated in 40 Korean VTE patients and 40 age-matched and sex-matched controls by real-time PCR followed by melting curve analysis and DNA sequence analysis.

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Article Synopsis
  • Determining the right warfarin dose and maintaining target PT-INR levels is difficult, with genetic differences potentially impacting individual dosage needs.
  • The study focused on Korean patients starting warfarin therapy, examining how the CYP2C9 and VKORC1 genes affect their response to the medication.
  • Findings revealed that specific genotypes were common among participants, and certain genetic variations led to differences in warfarin dosing and PT-INR responses, suggesting that genetic testing may help tailor anticoagulation therapy.
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