Skin-interfaced sweat monitoring patch constructed by flexible microfluidic capillary pump and Cu-MOF sensitized electrochemical sensor.

The limitations of skin-interfaced sweat monitoring are mainly reflected in the effective collection of sweat and the high sensitivity of the detection. This work proposes a new type of sweat monitoring patch based on a flexible microfluidic chip fabricated by a capillary pump and a copper-based metal-based organic framework (Cu-MOF) sensitized electrochemical sensor. The sweat in the microchannel is driven by a capillary pump to ensure the smooth collection and transportation.

Efficacy of platelet-rich plasma use as an adjunctive treatment in autologous osteochondral transplantation for patients with osteochondral lesions of the talus accompanied by chronic lateral ankle instability.

Background: Autologous osteochondral transplantation (AOT) combined with biological agents is an advanced technique for treating osteochondral lesions. Therefore, this study aimed to explore the effect of combining platelet-rich plasma (PRP) treatment with AOT on postoperative functional and magnetic resonance imaging (MRI) outcomes in patients with osteochondral lesions of the talus (OLTs) accompanied by chronic lateral ankle instability (CLAI).

Methods: This retrospective study had a minimum follow-up period of 1 year.

Tumor-Adhesive Chitosan-Derived Multi-Immune Agonist Unleashes Strong and Durable Anti-Cancer Immunity.

The immunomodulation of the tumor microenvironment is critical for effective cancer immunotherapy, particularly for tumors that exhibit limited responses to conventional treatments. However, current immune agonists developed for tumor immunomodulation face several challenges, such as poor intratumoral retention, inadequate biocompatibility, and restricted cellular targets, which ultimately hamper their therapeutic efficacy and clinical application. In this study, a tumor-adhesive chitosan-tethered immune agonist construct (TACTIC) is introduced, which demonstrates good biocompatibility and robust immunostimulatory effects, enhancing the immunogenicity of tumor cells while simultaneously stimulating pro-inflammatory responses in various immune cell populations.

Ion Substitution-Induced Distorted MOF Lattice with Deviated Energy and Dielectric Properties for Quasi-Solid-State Ion Conductor.

Solid-state electrolytes are currently receiving increasing interest due to their high mechanical strength and chemical stability for safe battery construction. However, their poor ion conduction and unclear conduction mechanism need further improvement and exploration. This study focuses on a hybrid solid-state electrolyte containing MOF-based scaffolds, using metal salts as the conductor.

The efficacy of notched music therapy vs conventional music therapy for chronic subjective tinnitus patients: a systematic review and meta-analysis.

Purpose: The etiology and mechanism of chronic subjective tinnitus (CST) are still unclear, thus there is no specific treatment yet. The notched music therapy (NMT) has been found to relieve patients' tinnitus symptoms, but its efficacy is still controversial. This study aims to resolve the controversy through meta pooling method.

[Characteristics of the Hearing Curves in 672 Tinnitus Patients and Their Relationship With Tinnitus Treatment Outcomes].

Objective: To analyze the characteristics of types of hearing curves in patients with tinnitus and the differences in tinnitus severity and treatment outcomes among patients with different types of hearing curves, to further explore the relationship between tinnitus and hearing loss, and to provide clinical evidence for exploring the etiology and treatment plans for tinnitus.

Methods: The basic information and the tinnitus and hearing data of the tinnitus patients who met the inclusion criteria were collected. The patients' severity of tinnitus was assessed on a scale of grades Ⅰ through Ⅴ according to the grading standards of the tinnitus evaluation questionnaire (TEQ).

Reconstruction of multiple volar finger defects with a single-pedicle five-lobed free SCIP flap: a case report of two patients.

Background: The management of extensive volar soft tissue defects in multiple fingers remains challenging for plastic surgeons. To date, although various types of flaps have been developed as reconstruction options, the applications remain limited by the shortcomings of bloated appearance, insufficient flap area, prolonged treatment time, persistent donor complications, and the sharply increased surgical complexity with the increased number of injured fingers. The superficial circumflex iliac artery perforator (SCIP) flap avoids the shortcomings of conventional flaps whilst allowing harvesting as a single-pedicle multiple-lobed form, rendering it the standout first-tier flap procedure in the repair of multiple soft tissue defects.

Continuous-variable multipartite entanglement in an integrated microcomb.

The generation of large-scale entangled states is crucial for quantum technologies, such as quantum computation, communication and metrology. Integrated quantum photonics that enables on-chip encoding, processing and detection of quantum light states offers a promising platform for the generation and manipulation of large-scale entangled states. Generating entanglement between qubits encoded in discrete variables within single photons is challenging, owing to the difficulty of making single photons interact on photonic chips.

Consonant aspiration in Mandarin-speaking children: a developmental perspective from perception and production.

Introduction: This study investigates Mandarin-speaking children's acquisition of aspirated/unaspirated voiceless consonants in terms of perception and production, to track children's developmental profile and explore the factors that may affect their acquisition, as well as the possible association between perception and production.

Methods: Mandarin-speaking children ( = 95) aged 3-5 and adults ( = 20) participated in (1) a perception test designed based on the minimal pairs of unaspirated/aspirated consonants in the quiet and noisy conditions respectively; (2) a production test where participants produced the target words, with syllable-initial consonants focusing on aspiration and non-aspiration. Six pairs of unaspirated/aspirated consonants in Mandarin were included.

PD(L)1 Inhibitors Plus Lenvatinib Vs Atezolizumab Plus Bevacizumab Combined With HAIC for Unresectable HCC: A Propensity Score Matching Study.

Purpose: To compare the clinical outcomes of different systemic therapies, specifically PD(L)1 inhibitors plus Lenvatinib versus Atezolizumab plus Bevacizumab, when combined with hepatic arterial infusion chemotherapy (HAIC) based on the FOLFOX regimen (oxaliplatin, fluorouracil, and leucovorin) as first line treatment for unresectable hepatocellular carcinoma.

Patients And Methods: This real-world retrospective study enrolled 294 patients with unresectable HCC. All patients received HAIC in combination with either PD(L)1 inhibitors plus Lenvatinib (PLEN-HAIC) or Atezolizumab plus Bevacizumab (AT-HAIC).

Comprehensive comparison on different wavelength selection methods using several near-infrared spectral datasets with different dimensionalities.

NIR spectroscopy is widely used in chemical analysis, agricultural science, food safety, and other fields, but its high dimensionality and data redundancy bring analytical challenges. This study aims to compare the performance of different wavelength selection methods in NIR spectral datasets with different dimensionalities to provide a reference for researchers. The wavelength selection methods in this study were classified into four categories according to their principles, which are partial least squares (PLS) parameter-based methods, intelligent optimization algorithms (IOA)-based methods, model population analysis (MPA)-based methods and wavelength interval selection (WIS) methods.

Detection of camellia oil adulteration based on near-infrared spectroscopy and smartphone combined with deep learning and multimodal fusion.

Camellia oil (CO) is known for its nutritional value and health benefits, but its high price makes it susceptible to adulteration. This study developed a binary adulteration system for CO in response to the adulteration of rapeseed oil (RO) into CO that been observed in the market. A total of 243 oil samples adulterated with various concentrations of RO were prepared.

Co-activating STING-TLR9 pathways promotes radiotherapy-induced cancer vaccination.

Vaccination may cure cancer patients by inducing tumor-specific immune responses. Radiotherapy is an appealing strategy to generate cancer vaccines in situ; thus far, however, only modest and short-lived immune responses are achieved. We here show that radiation combined with co-activating STING-TLR9 can generate powerful in situ cancer vaccines.

Vitexin alleviates MNNG-induced chronic atrophic gastritis via inhibiting NLRP3 inflammasome.

Ethnopharmacological Relevance: The dried fruit of Crataegus pinnatifida Bunge (Hawthorn in Chinese) is a traditional medicine used in China, Japan and Korea for thousands of years. Hawthorn is documented in the Chinese Pharmacopoeia, as a folk medicine that is used to eliminate food, strengthen the stomach, move qi and dissipate blood stasis, treat stagnation of meat and food, gastric distention and fullness, and has anti-inflammatory effects. Vitexin, a flavonoid glycoside, is an important biologically active compound derived from Hawthorn, with significant antioxidant and anti-inflammatory properties.

Percutaneous hepatic artery infusion chemotherapy with oxaliplatin and fluoropyrimidines in treatment-resistant colorectal cancer patients with unresectable liver metastases: a retrospective cohort study.

Background: Subsequent lines of therapy for chemotherapy-resistant metastatic colorectal cancer (CRC) have shown limited efficacy. Herein, we retrospectively investigated the efficacy and safety of hepatic artery infusion chemotherapy (HAIC) using oxaliplatin plus 5-FU/FUDR in patients with unresectable colorectal liver metastases (CRLM) who progressed following standard chemotherapy regimens.

Methods: From March 2017 to April 2023, CRC patients with unresectable CRLM who progressed following standard chemotherapy and subsequently received HAIC oxaliplatin plus 5-FU/FUDR were evaluated.

Safety and efficacy of adjuvant FOLFOX/FOLFIRI with versus without hepatic arterial infusion of floxuridine in patients following colorectal cancer liver metastasectomy (HARVEST trial): A randomized controlled trial.

Background: Hepatic artery infusion (HAI) chemotherapy, particularly with floxuridine (FUDR), has previously shown effectiveness in improving recurrence-free survival (RFS) in colorectal cancer (CRC) patients with colorectal liver metastases (CRLM). Nonetheless, its adjuvant use alongside modern systemic chemotherapy remains unevaluated.

Patients And Methods: The HARVEST trial is an open-label, randomized, controlled study conducted from May 2018 to August 2021.

Development of a neoadjuvant chemotherapy efficacy prediction model for nasopharyngeal carcinoma integrating magnetic resonance radiomics and pathomics: a multi-center retrospective study.

Objective: This study aimed to develop and validate a predictive model for assessing the efficacy of neoadjuvant chemotherapy (NACT) in nasopharyngeal carcinoma (NPC) by integrating radiomics and pathomics features using a particle swarm optimization-supported support vector machine (PSO-SVM).

Methods: A retrospective multi-center study was conducted, which included 389 NPC patients who received NACT from three institutions. Radiomics features were extracted from magnetic resonance imaging scans, while pathomics features were derived from histopathological images.

Generation, manipulation, detection and biomedical applications of magnetic droplets in microfluidic chips.

Microfluidic systems incorporating magnetic droplets have emerged as a focal point of significant interest within the biomedical domain. The allure of these systems lies in their capacity to offer precise control, enable contactless operation, and accommodate minimal sample concentration requirements. Such remarkable features serve to mitigate errors arising from human operation and other factors during cell or molecular detection.

N, P Co-Doped Hard Carbon Anodes for High-Performance Lithium-Ion Batteries with Enhanced Capacity Retention and Cycle Stability.

Compared to the traditional graphite anode, heteroatom-doped polymer carbon materials have high capacity retention due to their high porosity and porous structure. Therefore, they have great potential for application in lithium-ion battery (LIB) anodes. In this work, an N, P co-doped precursor polymer material (MBP), synthesized via a one-pot method using bisphenol-A (C-source), melamine (N-source), and 9,10-Dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (P-source).

Molecular Engineering Chemical Pre-lithiation Reagent with Low Redox Potential for Graphite Anode Enables High Coulombic Efficiency.

Graphite (Gr) is a low-cost and high-stability anode for lithium-ion batteries (LIBs). However, Gr anode exhibits an obstinate drawback of low initial Coulombic efficiency (ICE), owing to the active lithium loss for the solid electrolyte interphase (SEI) layer. Herein, a straightforward and effective chemical pre-lithiation strategy is proposed to compensate for the lithium loss.

Li-Si alloy pre-lithiated silicon suboxide anode constructing a stable multiphase lithium silicate layer promoting Ion-transfer kinetics.

Enhancing the initial Coulombic efficiency (ICE) and cycling stability of silicon suboxide (SiO) anode is crucial for promoting its commercialization and practical implementation. Herein, we propose an economical and effective method for constructing pre-lithiated core-shell SiO anodes with high ICE and stable interface during cycling. The lithium silicon alloy (LiSi) is used to react with SiO in advance, allowing for improved ICE of SiO without compromising its reversible specific capacity.

Clinical value of modified Shenling Baizhu powder in treating targeted therapy-induced diarrhea in non-small cell lung cancer.

Objective: To assess clinical value of modified Shenling Baizhu powder (, SBP) in intervening targeted therapy-induced diarrhea.

Methods: This study was a prospective randomized controlled study. Eighty-five non-small cell lung cancer (NSCLC) patients with diarrhea who took targeted drugs were randomly divided into two groups.