Low-Voltage Electrooxidation of Benzyl Alcohol to Benzoic Acid Enhanced by PtZn-ZnO Interface.

The electrocatalytic oxidation of benzyl alcohol to benzoic acid is a process that often requires high voltage, leading to increased energy consumption, side reactions (oxygen evolution reaction (OER)), and catalyst degradation. Herein, our study introduces a novel approach. We demonstrate that a PtZn-ZnO catalyst featuring a PtZn intermetallic structure with abundant PtZn-ZnO interfaces on the surface allows for the electrocatalytic oxidation of benzyl alcohol to benzoic acid with an impressive selectivity of 99.

Transcranial focused ultrasound modifies disease progression in SOD1 mouse model of amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis (ALS) is a progressively worsening neurodegenerative condition with very few treatment options available. Ultrasound neuromodulation offers promising benefits for treating neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. However, the effects and underlying mechanisms of ultrasound neuromodulation on ALS remain unclear.

Oxidative stress regulates the catalytic activity and mitochondrial localization of HK2 in trophoblast by regulating K346 lactylation.

Preeclampsia (PE) is one of the most dangerous complications of pregnancy. The pathogenic mechanisms of this condition are not yet clear. Lysine lactylation (Kla) is a novel post-translational modification (PTM) reported recently.

Effects of Different Kinds of Fruit Juice on Flavor Quality and Hypoglycemic Activity of Black Tea.

At present, the heavy bitter taste, poor flavor quality and low functional activity of summer and autumn tea are the bottleneck problems restricting the low utilization rate of summer and autumn tea resources. The research and development of new products of fruit-flavored black tea is conducive to expanding the utilization of summer and autumn tea resources. Different kinds of fruit juice were added during the fermentation and processing of classic black tea, such as bananas, apples, fragrant pear and Sydney pear, in this study.

Necroptosis-inducing nanobubbles for effective oxygen delivery and enhanced sonodynamic immunotherapy of breast cancer via UTND.

Purpose: Breast cancer (BC) is a global threat to female health. Sonodynamic therapy (SDT) has been shown to induce apoptosis in tumor cells and trigger immunogenic cell death, leading to the activation of antitumor immunity. However, the immunogenicity of this process may be compromised by oxidative stress and proteolysis.

Electrochemical reduction-induced oxygen vacancies and in-situ selenization strategies synergistically construct high-performance supercapacitors.

Supercapacitors encounter difficulties in terms of slow kinetics. The development of supercapacitors with fast reaction kinetics is a significant challenge. This work presents the synthesis ofnickel foam (NF)-supported CoMn layered double hydroxides (CoMn-LDH) and CoSe composites (O-CoMn-LDH@CoSe/NF) were synthesized using electrochemical reduction-induced oxygen vacancy (O) and in situ selenization strategies.

Clinical Outcomes of Neoadjuvant Therapy Versus Upfront Surgery in Resectable Pancreatic Cancer: Systematic Review and Meta-analysis of Latest Randomized Controlled Trials.

Background: Survival and surgical benefits of neoadjuvant treatments (NAT) in resectable pancreatic cancer (RPC) remains unclear. The role of NAT in providing additional benefits to reduce biological aggressiveness and recurrence is worth elucidating. We assessed the latest randomized controlled trials (RCTs).

The positive correlation between amphiregulin and insulin resistance.

Objective: Obesity and insulin resistance carry a high risk of progressing to type 2 diabetes mellitus. A lot of evidence has tightly associated insulin resistance with chronic inflammation. Besides, it has been reported that the activation of amphiregulin epidermal growth factor receptor pathways is involved in chronic inflammation.

Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review.

With the consistent occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the prevalence of various ocular complications has increased over time. SARS-CoV-2 infection has been shown to have neurotropism and therefore to lead to not only peripheral inflammatory responses but also neuroinflammation. Because the receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), can be found in many intraocular tissues, coronavirus disease 2019 (COVID-19) may also contribute to persistent intraocular neuroinflammation, microcirculation dysfunction and ocular symptoms.

A predicting model for intrapartum cesarean delivery at admission using a nomogram: a retrospective cohort study in China.

Background: With the implementation of China's three-child policy, an increasing number of Chinese women are not opting for cesarian delivery (CD), with particular concern about intrapartum CD. At the same time, reducing the rate of intrapartum CD is closely associated with a decrease in maternal and neonatal complications, as well as an improvement in maternal satisfaction. Therefore, it is essential to develop a predictive model specifically tailored to Chinese pregnant women to reduce the rate of intrapartum CD.

A Rare Case With Mixed Growth of Facial Nerve Neurofibroma and Schwannoma Without Facial Paralysis.

Facial neuromas are benign with a common clinical manifestation of gradual or sudden peripheral facial nerve paralysis. This study reports an atypical case of facial neuroma in the absence of facial nerve paralysis and discusses the diagnosis and pathophysiological features. A rare case of extensive facial neuroma histopathologically confirmed as a mixed growth of schwannoma and neurofibroma in a 51-year-old man was described.

First-Line Camrelizumab Versus Placebo Plus Chemotherapy With or Without Radiotherapy for Brain Metastases in NSCLC: The CTONG 2003 Randomized Placebo-Controlled Trial.

Introduction: Retrospective studies have indicated the potential benefits of immunotherapy for brain metastases (BMs) in NSCLC. To our knowledge, CTONG 2003 is the first randomized controlled trial to evaluate camrelizumab for untreated BM of NSCLC.

Methods: CTONG 2003 is a multicenter, randomized, double-blind, placebo-controlled trial.

Exercise-induced Sesn2 mediates autophagic flux to alleviate neural damage after ischemic stroke in mice.

Background: We previously demonstrated that exercise pretreatment can suppress oxidative stress and neuroinflammation following ischemic stroke. However, the specific mechanisms underlying these effects are uncertain. Sestrin2 (Sesn2), a stress-responsive protein, has been reported to reduce neuroinflammation and protect against ischemic cerebral injury.

High-performance anion exchange membranes based on poly(oxindole benzofuran dibenzo-18-crown-6)s functionalized with hydroxyl and quaternary ammonium groups for alkaline water electrolysis.

Anion exchange membranes (AEMs) play a vital role in AEM water electrolysis (AEMWE), a promising technology for hydrogen production. However, developing AEMs that simultaneously achieve high OH conductivity, robust alkaline stability and sustained operational performance in AEMWE remains challenging. In the present study, we report on a class of high-performance, readily synthesized AEMs based on poly(oxindole benzofuran dibenzo-18-crown-6)s functionalized with hydroxyl and quaternary ammonium groups.

Efficacy and safety of switching from entecavir to tenofovir alafenamide in chronic hepatitis B patients with low-level viremia: a real-world 48-week extension study.

Chronic hepatitis B (CHB) patients receiving entecavir (ETV) treatment might develop low-level viremia (LLV), which is proven to be associated with worse clinical outcomes, such as risk of drug-related mutations, progression to cirrhosis, and even hepatocellular carcinoma. This real-world prospective study evaluated the efficacy and safety of switching from ETV to tenofovir alafenamide fumarate (TAF) in CHB patients with LLV. From August 2020 to August 2023, 351 ETV-experienced CHB patients with LLV were enrolled from eight hospitals.

The crosstalk between SND1 and PDCD4 is associated with chemoresistance of non-small cell lung carcinoma cells.

Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is highly resistant to chemo- or radiation therapy, which poses a huge challenge for treatment of advanced NSCLC. Previously, we demonstrated the oncogenic role of Tudor Staphylococcal nuclease (TSN, also known as Staphylococcal nuclease domain-containing protein 1, SND1), in regulating chemoresistance in NSCLC cells.

Structure-Guided Optimization and Preclinical Evaluation of 6--Benzylguanine-Based Pin1 Inhibitor for Hepatocellular Carcinoma Treatment.

Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths globally, and the need for effective systemic therapies for HCC is urgent. Our previous work reveals that Pin1 is a potential anti-HCC target, which regulates miRNA biogenesis and identifies as a novel Pin1 inhibitor to suppresses HCC. However, a great demand in HCC therapy as well as the limited chemical stability and pharmacokinetic feature of motivated us to find improved Pin1 inhibitors.

The Impact of COVID-19 Pandemic on the Diagnosis, Treatment, and Outcomes of Colorectal Cancer in Singapore.

: During the COVID-19 pandemic, many countries implemented lockdowns and social distancing measures, which may delay the early diagnosis of colorectal cancer (CRC). This study aims to review the impact of the pandemic on the diagnosis and treatment outcomes of CRC. : Patients who underwent colonoscopy or surgery for CRC were included.

Effects of Bile Acids on Growth Performance, Hepatopancreatic Antioxidant Capacity, Intestinal Immune-Related Gene Expression, and Gut Microbiota of .

This study aimed to examine the impact of varying concentrations of bile acids (BA) added to the feed on several aspects of . The purity of BA was 25.29%, and its main components were 5.

Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages.

Hyperglycemia and bacterial colonization in diabetic wounds aberrantly activate Nod-like receptor protein 3 (NLRP3) in macrophages, resulting in extensive inflammatory infiltration and impaired wound healing. Targeted suppression of the NLRP3 inflammasome shows promise in reducing macrophage inflammatory disruptions. However, challenges such as drug off-target effects and degradation via lysosomal capture remain during treatment.

Investigating the dual causative pathways linking immune cells and venous thromboembolism via Mendelian randomization analysis.

Background: Venous thromboembolism (VTE) is a common vascular disease with a significant global burden, influenced by multiple factors, such as genetic, environmental, and immune components. Immune responses and shifts in immune cell profiles are closely linked to the development and progression of VTE, yet current studies are limited by confounding factors and reverse causation. To address these limitations, this study uses Mendelian randomization to explore the causal relationship between immune cell traits and VTE, aiming to provide insights into underlying mechanisms.

Total saponin extracts of Pseudostellaria heterophylla ameliorates meibomian gland dysfunction through SCD1/SPT1/ceramide axis.

Ethnopharmacological Relevance: Pseudostellaria heterophylla (Tài Zǐ Shēn, TZS) is a traditional Chinese medicine with spleen and qi benefits. Its immunomodulatory, anti-fatigue, anti-stress, and lipid metabolism regulation effects have been clinically confirmed, but its role in meibomian gland dysfunction (MGD) is still unclear.

Aim Of The Study: This study aims to investigate the effect and mechanism of action of TZS in treating MGD.

Multifunctional Artificial Electric Synapse of MoSe-Based Memristor toward Neuromorphic Application.

Research on memristive devices to seamlessly integrate and replicate the dynamic behaviors of biological synapses will illuminate the mechanisms underlying parallel processing and information storage in the human brain, thereby affording novel insights for the advancement of artificial intelligence. Here, an artificial electric synapse is demonstrated on a one-step Mo-selenized MoSe memristor, having not only long-term stable resistive switching characteristics (reset 0.51 ± 0.