A simple synthesis of a core-shell structure PPy-Au nanocomposite for immunosensing of C-reactive protein.

High-sensitivity C-reactive protein (hs-CRP) is an inflammatory biomarker and can accurately predict the development of cardiovascular disease (CVD). We synthesized a core-shell structure PPy-Au nanocomposite in situ by chemically oxidizing pyrrole (Py) with HAuCl and the produced Au nanoparticles realized the doping in the polymerization. Analysis of morphology and energy spectrum as well as electrochemical characterization confirmed the successful one-pot synthesis.

Electrochemical sensor for ultrasensitive sensing of biotin based on heme conjugated with gold nanoparticles and its electrooxidation mechanism.

We report the fabrication of a facile sensor using heme conjugated with gold nanoparticles (AuNPs) in situ on a glass carbon electrode (GCE) for the ultrasensitive determination of biotin without antibody or streptavidin. The use of heme and AuNPs as dual amplifiers allows a very broad detection range from 0.0050 to 50.

A facile indole probe for ultrasensitive immunosensor fabrication toward C-reactive protein sensing.

C-reactive protein (CRP) is a protein biomarker for acute phase response. Herein, we fabricate a highly sensitive electrochemical immunosensor for CRP on a screen-printed carbon electrode (SPCE) with indole as a novel electrochemical probe and Au nanoparticles for signal amplification. Amongst, indole appeared as transparent nanofilms on the electrode surface, and underwent a one-electron and one-proton transfer to form oxindole during the oxidation process.

Sexual conflict and the function of genitalic claws in guppies (Poecilia reticulata).

Poeciliid fish, freshwater fish with internal fertilization, are known for the diversity of structures on the male intromittent organ, the gonopodium. Prominent among these, in some species, is a pair of claws at its tip. We conducted a manipulative study of these claws in the guppy, Poecilia reticulata, to determine if these aid in transferring sperm to resistant females.