Publications by authors named "Yun Young Roh"
Introduction: An easy-to-implement and accurate lung function assessment tool for preterm infants is crucial to manage lifelong respiratory morbidities. We aimed to determine which pulmonary function parameters in preterm infants can predict the trajectory of airway obstruction and asthma development after 4 years of age.
Methods: We evaluated 52 preterm infants who had undergone both tidal breathing flow-volume loop (TBFVL) and multiple-breath washout (MBW) analyses in infancy and spirometry after the age of 4 years.
Pulmonary function characteristics in children with suspected asthma: implications for asthma diagnosis.
Asian Pac J Allergy Immunol
April 2024
Article Synopsis
- A study investigated the pulmonary function of children suspected of having asthma who did not show a bronchodilator response (BDR) or bronchial hyperresponsiveness (BHR).
- It analyzed data from two cohorts totaling 1,304 children and found that many in the "probable asthma" group displayed increased levels of fractional exhaled nitric oxide (FeNO) and allergic sensitization, indicating airway dysfunction.
- Results showed that lung function metrics decreased progressively from non-asthma to probable asthma and then to definite asthma, highlighting distinct patterns in the pulmonary function tests between these groups.
Predicting the Outcome of Pediatric Oral Food Challenges for Determining Tolerance Development.
Allergy Asthma Immunol Res
March 2024
Article Synopsis
- - The study aimed to evaluate oral food challenges (OFCs) in children to help predict which ones have developed immune tolerance to specific food allergens, despite the risks associated with these challenges.
- - A total of 432 pediatric OFCs were analyzed, focusing on clinical characteristics and specific IgE levels for allergens like eggs and milk, with findings indicating that lower food-specific IgE levels correlated with successful tolerance confirmation.
- - The researchers created a prediction model using variables such as total IgE, food-specific IgE, and age, which could assist clinicians in safely determining when to conduct OFCs and reintroduce foods to children with allergies.
Article Synopsis
- The RALE score effectively quantifies lung edema and serves as a promising prognostic marker for mortality in children suffering from acute respiratory distress syndrome (ARDS).
- Among 296 children studied, the RALE score demonstrated strong reliability and was correlated with other indicators of ARDS severity, indicating its potential as a useful tool in clinical settings.
- The study found that a higher RALE score is linked to increased ARDS-specific mortality, allowing clinicians to make better-informed decisions regarding treatment and fluid management for affected children.
Hepatic veno-occlusive disease (VOD) is a serious systemic endothelial complication after stem cell transplantation. Defibrotide is under investigation as a prophylactic agent for VOD; however, high costs limit its utility. We evaluated the prophylactic efficacy of a low-dose defibrotide regimen for VOD.
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