Curcumin ameliorates dextran sulfate sodium-induced experimental colitis by blocking STAT3 signaling pathway.

Background And Aims: Although a series of studies have shown that curcumin can exert anti-inflammatory effects in colitis by inhibiting NF-κB activation, whether these anti-inflammatory effects of curcumin are also attributed to its ability to inhibiting STAT3 pathway has never been tested in experimental colitis to date. The purpose of the study was to investigate whether curcumin could exert its therapeutic effects in experimental colitis by inhibiting STAT3 pathway.

Materials And Methods: Curcumin was administered in experimental colitis induced by dextran sulfate sodium (DSS).