Gene expression is associated with brain function of insomnia disorder, rather than brain structure.

Previous research has found brain structural and functional abnormalities in patients with insomnia disorder (ID). However, the relationship between brain abnormalities in ID and brain gene expression is unclear. This study explored the relationship between gene expression and brain structural or functional abnormalities in ID, and we validated the reliability of the results with two independent datasets (discover dataset: healthy control (HC) = 129, ID = 264; validation dataset: HC = 160, ID = 115).

A Rapid Colorimetric and Fluorescent Assay of in Food by Loop-Mediated Isothermal Amplification.

is a foodborne mycete that can induce recurrent pneumonia, but the current detection methods have insufficient sensitivity and rapidity. Here, we aim to develop an efficient and sensitive loop-mediated isothermal amplification (LAMP) primer set for detection. First, we designed a novel set of LAMP primers by targeting the gene.

Zr-Doping Strategy of High-Quality CuO/β-GaO Heterojunction for Ultrahigh-Performance Solar-Blind Ultraviolet Photodetection.

β-GaO, as an ultrawide band gap semiconductor, has emerged as the most promising candidate in solar-blind photodetectors. The practical application of β-GaO, however, suffers from intrinsic defects and suboptimal crystal quality within the devices. In this work, high-quality β-GaO was successfully synthesized by employing the Zr-doping strategy, which has facilitated the development of ultrahigh-performance solar-blind photodetectors based on CuO/β-GaO heterostructures.

Immune cell changes in infection-induced glandular epithelial cell damage of the gastric mucosa.

Objective: The purpose of this study was to investigate the relationship between () infection-induced changes in gastric mucosal immune cells and glandular epithelial cell damage and the histopathological characteristics of these changes.

Methods: We performed a detailed histomorphometry and immunohistochemical analysis of a total of 1635 -infected gastric mucosal specimens.

Results: Stage-wise features were as follows: Early stage of infection: was colonized in the mucous layer, and very few neutrophils were visible in the layer.

Familial adult-onset neuronal intranuclear inclusion disease: A case report and literature review.

Rationale: Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder with highly variable clinical manifestations, making diagnosis challenging. Recent advancements in genetic and pathological testing, such as the identification of GGC repeat expansions in the NOTCH2NLC gene, have improved diagnostic accuracy, but familial cases remain underreported.

Patient Concerns: This report details 3 cases of familial adult-onset NIID in 2 sisters and 1 brother.

Effect of thrombolytic therapy with rt-PA at different times on neurological function and complications in patients with acute cerebral infarction.

This study investigates the effects of rt-PA thrombolytic therapy at varying times on neurological function and complications in acute cerebral infarction (ACI) patients. A total of 120 ACI patients admitted between August 2019 and July 2021 were divided into three groups based on the timing of rt-PA treatment: <3h (40 patients), 3-4.5h (55 patients), and >4.

Two O-methyltransferases are responsible for multiple O-methylation steps in the biosynthesis of furanocoumarins from Angelicadecursiva.

Angelica decursiva, an important traditional medicinal plant, possesses a unique pharmacological activity. Its principal active ingredients are coumarins, including scopoletin, bergapten, and imperatorin. However, the enzymes catalyzing the critical step of coumarins biosynthesis pathway remain unidentified.

Reliability and Availability of the 2017 EULAR-OMERACT Scoring System for Ultrasound Synovitis Assessment: Results From a Training and Reading Exercise.

Objective: To evaluate the availability and reliability of the European League Against Rheumatisms Outcome Measures in Rheumatology Synovitis (EULAR-OMERACT) scoring system among radiologists with different levels of musculoskeletal ultrasound (US) experience in assessing synovitis in patients with rheumatoid arthritis (RA).

Method: The patients with RA were retrospectively recruited from January 2020 to March 2022. Five radiologists with different levels of US experience were recruited for the reader study (R1-5), which included two parts.

The deubiquitinase OTUD3 stabilizes IRP2 expression to reduce hippocampal neuron ferroptosis via the p53/PTGS2 pathway to ameliorate cerebral ischemia-reperfusion injury.

Background: Ischemic stroke (IS) is known for its high morbidity, disability and mortality rates, and studies designed to explore its pathophysiological mechanisms and identify novel therapeutic strategies are urgently needed. We aimed to probe the effects of the deubiquitinase OTUD3-IRP2-p53/PTGS2 pathway on cerebral ischemia‒reperfusion (I/R) injury and hippocampal neuron ferroptosis.

Methods: A cerebral I/R mouse model was established.

Extraction of curcuminoids from Curcuma longa L. by fatty acid-based ionic liquid aqueous solution: Experimental and mechanism study.

Curcuminoids originated from the plant Curcuma longa L. show high medical values. Herein, ionic liquids (ILs) were synthesized using fatty acids and alcohol amines to extract curcuminoids.

Chiral Hydrogel Nerve Conduit Boosts Peripheral Nerve Regeneration via Regulation of Schwann Cell Reprogramming.

The Schwann cell (SC) is essential in peripheral nerve regeneration by reprogramming into a stem-like "repair Schwann cell" (rSC) phenotype; however, maintaining the rSC stemness remains an unmet challenge. Chirality is a fundamental factor controlling cell fate, and its potential role in regulation of SC reprogramming has long been ignored and remains poorly understood. Herein, inspired by natural chiral components in the SC microenvironment, chiral hydrogel nerve conduits are prepared by supramolecular assembly of l/d-phenylalanine derivatives (l/d-Phe) in polymeric chitosan-gelatin conduits.

Efficacy of Preoperative Autologous Blood Donation for Surgical Treatment of Thoracic Spinal Stenosis: A Propensity-Matched Cohort Study.

Objective: Thoracic spinal stenosis (TSS) surgeries necessitate a substantial amount of allogeneic blood resources. However, the efficacy of preoperative autologous blood donation (PABD) in TSS surgery has not been clearly evaluated. Therefore, we aimed to evaluate the efficacy of PABD for TSS surgery.

Enhanced diversity on connector hubs following sleep deprivation: Evidence from diffusion and functional magnetic resonance imaging.

Sleep deprivation has been demonstrated to exert widespread and intricate impacts on the brain network. The human brain network is a modular network composed of interconnected nodes. This network consists of provincial hubs and connector hubs, with provincial hubs having diverse connectivities within their own modules, while connector hubs distribute their connectivities across different modules.

Algicidal bacteria-derived membrane vesicles as shuttles mediating cross-kingdom interactions between bacteria and algae.

Bacterial membrane vesicles (BMVs) are crucial biological vehicles for facilitating interspecies and interkingdom interactions. However, the extent and mechanisms of BMV involvement in bacterial-algal communication remain elusive. This study provides evidence of BMVs delivering cargos to targeted microalgae.

Interfacial Electronic Interactions Promoted Activation for Nitrate Electroreduction to Ammonia over Ag-Modified CoO.

Electrocatalytic nitrate (NO ) reduction to ammonia (NRA) offers a promising pathway for ammonia synthesis. The interfacial electronic interactions (IEIs) can regulate the physicochemical capabilities of catalysts in electrochemical applications, while the impact of IEIs on electrocatalytic NRA remains largely unexplored in current literature. In this study, the high-efficiency electrode Ag-modified CoO (AgCo/CC) is prepared for NRA in neutral media, exhibiting an impressive nitrate conversion rate of 96.

TiCT/CdZnS composites constructed of Schottky heterojunction for efficient photocatalytic reduction of U(VI).

Photocatalysis has emerged as a extremely promising green technology for the treatment of uranium-containing wastewater. This study focuses on the fabrication of TiCT/CdZnS composites with Schottky junctions through the in-situ growth of CdZnS on TiCT nanosheets, enabling efficient photoreduction of U(VI) without the requirement of sacrificial agents. The results demonstrate that the TiCT/CdZnS composites achieve remarkable 99.

Effect of Home-Based Cardiac Telerehabilitation in Patients After Percutaneous Coronary Intervention: A Randomized Controlled Trial.

Low adherence to hospital-based cardiac rehabilitation has been observed in patients after percutaneous coronary intervention. The effectiveness of home-based cardiac telerehabilitation in this setting is unclear. This study aimed to investigate the impact of home-based cardiac telerehabilitation on exercise endurance, disease burden status, cardiac function, and quality of life in patients after percutaneous coronary intervention.