Background: The incidence of ulcerative colitis (UC) is on the rise globally and the development of drugs targeting UC is urgent. Finding the target of action of natural products is important for drug discovery, elucidation of drug action mechanism, and disease mechanism. San-Ye-Qing (SYQ), is an ancient herbal medicine, but whether the powder of its rhizome has pharmacological effects against UC and its mechanism of action are not clear.
View Article and Find Full Text PDFBackground: Tartrate-resistant acid phosphatase (ACP5) has been implicated in the progression of most malignant tumors, but its role in pancreatic cancer (PC) remained unclear. Thus, this study aimed to elucidate the role and function of ACP5 in PC progression.
Methods: The expression of ACP5 in PC samples was assessed via R programming, TNM plot, and Gene Expression Profiling Interactive Analysis (GEPIA).
Background: The persistence of threatened and protected wildlife depends not only on habitat suitability but also remarkably on local communities' acceptance. The black-necked crane (Grus nigricollis) is a flagship species for conservation on the plateau in western China. However, the human dimension has been completely ignored in the decision-making process for conservation.
View Article and Find Full Text PDFBackground: Irisin, an exercise-induced myokine and adipocytokine, has been reported to decrease in type 2 diabetic patients. Recently, several research studies indicated that circulating levels were correlated with bone mineral density (BMD). To evaluate bone metabolism, bone turnover markers (BTMs) should be included.
View Article and Find Full Text PDFJ Gastrointest Oncol
December 2021
Background: Hepatocellular carcinoma (HCC) is a leading cause of global cancer-related mortality and the most common form of liver cancer. (RNA exonuclease 4 homolog) downregulation has previously been linked to enhanced chemosensitivity in breast cancer cells. The present study sought to comprehensively clarify the functional role of in HCC.
View Article and Find Full Text PDFThe placenta may play a key role in the activation of inflammation and initiation of insulin resistance (IR) during gestational diabetes mellitus (GDM) pathogenesis. Interleukin (IL)-1β and IL-18, regulated by NLR family pyrin domain containing-3 (NLRP3) inflammasome, are important inflammatory cytokines in the initiation of maternal IR during GDM. However, the mechanism responsible for the regulatory of NLRP3 inflammasome in placenta remains unknown.
View Article and Find Full Text PDFStep emulsification is a low-shear method to produce monodispersed microdroplets by spontaneous breakup of dispersed fluid at a spatial "step". As a semi-open microfluidic system, controllable coalescence of multiple components in step emulsification has not been achieved. Here, we use a low voltage to control the coalescence position of flow tips in the terrace.
View Article and Find Full Text PDFActivation of the NACHT leucine rich repeat and pyd domains-containing 3 (NLRP3) inflammasome plays an important role in the initiation of inflammation in adipose tissue in diabetic patients. However, the mechanisms underlying this are not fully understood. Hydrogen sulfide (HS) has been shown to have anti-inflammatory properties in various cell types.
View Article and Find Full Text PDFAeration strategy played an important role in reactor performance. In this study, when superficial upflow air velocity (SAV) decreased from 0.16 to 0.
View Article and Find Full Text PDFIn the present study, we investigate the effect of reduced cystathionine-γ-lyase (CSE) expression in high glucose induced metalloproteinases14 (MMP14) expression in adipocytes and visceral adipose tissues. Diabetic mice were prepared by injections of STZ and the expression of CSE, MMP14 in visceral adipose tissues were determined. Adipocytes were differentiated from 3T3-L1 cells and treated with high glucose (HG), HS slow-releasing compound GYY4137 or transfected with CSE siRNA.
View Article and Find Full Text PDFA simple capillary electrophoretic method based on 1-phenyl-3-methyl-5-pyrazolon (PMP) derivatization has been developed for simultaneous separation and determination of nine aldoses (xylose, arabinose, glucose, rhamnose, fucose, galactose, mannose, glucuronic acid and galacturonic acid). The separation of PMP-labeled monosaccharide derivatives was carried out in uncoated capillary (48.5 cm x 75 microm i.
View Article and Find Full Text PDFWater-soluble polysaccharide from Gynostemma pentaphyllum herb tea (PSGP) was isolated by hot-water extraction and ethanol precipitation. The chemical components and preliminary immunomodulating activity of PSGP were investigated both in vitro and in vivo. Capillary zone electrophoresis analysis showed that PSGP was a typical nonstarch heteropolysaccharide, with glucose being the main component monosaccharide (23.
View Article and Find Full Text PDFThree Angelica sinensis polysaccharide fractions (APFs), named APF1, APF2 and APF3, were isolated and purified from Radix A. sinensis and their antioxidant activities were evaluated in isolated mouse peritoneal macrophages by pretreatment with APFs before exposure to 0.2 mM tertbutylhydroperoxide (t-BHP).
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