Chemical Constituents of Halophyte and Their Therapeutic Potential for Hair Loss.

, a halophyte in the Amaranthaceae family, exhibits remarkable resilience to high salt and alkali stresses despite the absence of salt glands or vesicles in its leaves. While there is growing pharmacological interest in , research on its secondary metabolites remains limited. In this study, chemical constituents of the aerial parts of were identified using 1D- and 2D-NMR experiments, and its biological activity concerning hair loss was newly reported.

Sesquiterpene Lactones with Anti-Inflammatory Activity from the Halophyte DC.

There were five sesquiterpene lactones, belonging to the eudesmanolide class, isolated from the halophyte DC. The structures of the compounds were determined using spectroscopic methods, including 1D and 2D NMR spectra, MS data, and optical rotation values. Compounds and were characterized by the position of -hydroxyphenylacetyl group in the sugar moiety.

Stereochemical Determination of Fistularins Isolated from the Marine Sponge and Their Regulatory Effect on Intestinal Inflammation.

By activity-guided fractionation based on inhibition of nitric oxide (NO) and prostaglandin E2 (PGE), six fistularin compounds (-) were isolated from the marine sponge (order Astrophorida). Based on stereochemical structure determination using Mosher's method, fistularin-3 was assigned as a new stereoisomer. On the basis of the stereochemistry of fistularin-3, the stereochemical homogeneity of all six compounds was established by comparing carbon and proton chemical shifts.

Isoquinolinequinone Derivatives from a Marine Sponge ( sp.) Regulate Inflammation in In Vitro System of Intestine.

Using bio-guided fractionation and based on the inhibitory activities of nitric oxide (NO) and prostaglandin E2 (PGE2), eight isoquinolinequinone derivatives (-) were isolated from the marine sponge sp. Among these, methyl -demethylrenierate () is a noble ester, whereas compounds and are new -demethyl derivatives of known isoquinolinequinones. Compound was assigned as a new 21-dehydroxyrenieramycin F.

Standardized Fraction of Alleviates Dextran Sulfate Sodium-Induced Chronic Colitis in C57BL/6 Mice via Upregulation of FOXP3 Regulatory T Cells.

is a tropical brown algae (seaweed) known to have anti-inflammatory properties. In this study, we analyzed extract (TOE) using liquid chromatography quadrupole time of flight mass spectrometry (LC-QTOF-MS) and nuclear magnetic resonance (NMR) and evaluated the in vivo efficacy of TOE against dextran sulfate sodium-induced chronic colitis in C57BL/6 mice. The bioactive fraction of TOE was administered orally daily for 6 weeks to mice under different treatments normal, colitis, and colitis + conventional drug (5-aminosalicylic acid, 5-ASA).

The Effects of Extract on Testosterone-Induced Benign Prostatic Hyperplasia in Rats, and Quantitative Analysis of Major Constituents Depending on Extract Conditions.

This study aimed to investigate the beneficial effects of on testosterone propionate (TP)-induced benign prostatic hyperplasia (BPH) in Wistar rats. Moreover, the bioactive constituents in the extract were determined using LC/MS and HPLC analyses. The dried fruits of were extracted using accelerated solvent extraction (ASE) under different extract conditions (temperature, 30 C or 100 C; extract solvent, 60% or 100% ethanol) to yield four extracts (T1~T4).

Deacetylphylloketal, a New Phylloketal Derivative from a Marine Sponge, Genus , with Potent Anti-Inflammatory Activity in In Vitro Co-Culture Model of Intestine.

The inflammatory bowel diseases (IBD) cause chronic inflammation of the gastrointestinal tract and include ulcerative colitis (UC) and Crohn's disease (CD). The prevalence of IBD has been increasing worldwide, and has sometimes led to irreversible impairment of gastrointestinal structure and function. In the present study, we successfully isolated a new phylloketal derivative, deacetylphylloketal () along with four known compounds from the sponge genus The anti-inflammatory properties of deacetylphylloketal () and phyllohemiketal A () were evaluated using an in vitro co-culture system that resembles the intestinal epithelial environment.

(10)-Debromohymenialdisine from Marine Sponge sp. Regulates Intestinal Inflammatory Responses in Co-Culture Model of Epithelial Caco-2 Cells and THP-1 Macrophage Cells.

Crohn's disease (CD) and ulcerative colitis (UC), collectively referred to as inflammatory bowel disease (IBD), are autoimmune diseases characterized by chronic inflammation within the gastrointestinal tract. Debromohymenialdisine is an active pyrrole alkaloid that is well known to serve as a stable and effective inhibitor of Chk2. In the present study, we attempted to investigate the anti-inflammatory properties of (10)-debromohymenialdisine () isolated from marine sponge species using an intestinal in vitro model with a transwell co-culture system.

Antiobesity Effect of Fermented Chokeberry Extract in High-Fat Diet-Induced Obese Mice.

Black-fruited chokeberries (Aronia melanocarpa), growing mainly in the Central and Eastern European countries, have health benefits due to the high concentrations of polyphenolic compounds. However, a strong bitter taste of chokeberries limits its usage as functional food. We hypothesized that the fermented A.

Chokeberry Extract and Its Active Polyphenols Suppress Adipogenesis in 3T3-L1 Adipocytes and Modulates Fat Accumulation and Insulin Resistance in Diet-Induced Obese Mice.

Berries of (chokeberry) are known to be a rich source of biologically active polyphenols. In the present study, the effects of seven anti-adipogenic polyphenolic phytochemicals isolated from methanol extract on adipogenic transcription factors were investigated. Amygdalin and prunasin were found to inhibit 3T3-L1 adipocyte differentiation by suppressing the expressions of PPARγ (peroxisome proliferator-activated receptor γ), C/EBPα (CCAAT/enhancer binding protein α), SREBP1c (sterol regulatory element binding protein 1c), FAS (fatty acid synthase), and aP2 (adipocyte fatty-acid⁻binding protein).

Estrogenic activity of constituents from the rhizomes of Rheum undulatum Linné.

Stilbenes have been reported to be phytoestrogen compounds owing to its structural similarity to the estrogenic agent diethylstilbestrol. To find new stilbene-derivative phytoestrogens, isolation of stilbene-rich R. undulatum was performed and led to identify six new compounds (1-5 and 28), one newly determined absolute configurations compound (27) together with 21 previously reported compounds (6-26).

Identification of Hepatoprotective Constituents in and Development of Simultaneous Analysis Method using High-performance Liquid Chromatography.

Background: , a naturally salt-tolerant halophyte, has been studied recently and is of much interest to researchers due to its potent antioxidant and hepatoprotective activities.

Objective: In the present study, we attempted to elucidate bioactive compounds from ethyl acetate (EtOAc) soluble fraction of extract. Furthermore, the simultaneous analysis method of bioactive EtOAc fraction of has been developed using high-performance liquid chromatography (HPLC).