Aim: To reveal the cytotoxicity and related mechanisms of gatifloxacin (GFX) to stromal fibroblasts (SFs)
Methods: SFs were treated with GFX at different concentrations (0.009375%-0.3%), and their viability was detected by MTT method.
Toxicol Res (Camb)
September 2016
Proparacaine (PPC) is a widely used topical anaesthetic in the eye clinic; its abuse may damage the cornea and result in impairment of vision. Although PPC has been reported to be cytotoxic to human keratocytes, there is no scientific report about its toxic mechanisms in human corneal stroma. Here, we evaluated the cytotoxicity of PPC to corneal stroma in an model of human corneal stromal (HCS) cells and an model of cat corneas.
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