Hydroxylation Strategy Enables Ru-Mn Oxide for Stable Proton Exchange Membrane Water Electrolysis under 1 A cm.

Ruthenium (Ru)-based catalysts have demonstrated promising utilization potentiality to replace the much expensive iridium (Ir)-based ones for proton exchange membrane water electrolysis (PEMWE) due to their high electrochemical activity and low cost. However, the susceptibility of RuO-based materials to easily be oxidized to high-valent and soluble Ru species during the oxygen evolution reaction (OER) in acid media hinders the practical application, especially under current density above 500 mA cm. Here, a manganese-doped RuO catalyst with the hydroxylated metal sites (i.

CPhaMAS: The first pharmacokinetic analysis cloud platform developed by China.

Objectives: Software for pharmacological modeling and statistical analysis is essential for drug development and individualized treatment modeling. This study aims to develop a pharmacokinetic analysis cloud platform that leverages cloud-based benefits, offering a user-friendly interface with a smoother learning curve.

Methods: The platform was built using Rails as the framework, developed in Julia language, and employs PostgreSQL 14 database, Redis cache, and Sidekiq for asynchronous task management.

Pharmacokinetic-pharmacodynamic Modelling of NH600001 in Healthy Subjects and Patients Undergoing Gastroscopy.

NH600001 is a new general anaesthetic drug with a structure similar to etomidate. The objective of this study was to investigate the relationship between concentrations of NH600001 and sedation efficacy based on data from phase I-II studies and factors influencing the pharmacokinetics and pharmacodynamics of NH600001. The dataset consisted of 2 phase I studies in healthy subjects and 1 phase II study in patients undergoing gastroscopy.

Ampere-Level Hydrogen Generation via 1000 H Stable Seawater Electrolysis Catalyzed by Pt-Cluster-Loaded NiFeCo Phosphide.

Seawater electrolysis can generate carbon-neutral hydrogen but its efficiency is hindered by the low mass activity and poor stability of commercial catalysts at industrial current densities. Herein, Pt nanoclusters are loaded on nickel-iron-cobalt phosphide nanosheets, with the obtained Pt@NiFeCo-P electrocatalyst exhibiting excellent hydrogen evolution reaction (HER) activity and stability in alkaline seawater at ampere-level current densities. The catalyst delivers an ultralow HER overpotential of 19.

Pressure-Dependent CO Electroreduction to Methane over Asymmetric Cu-N Single-Atom Sites.

Single-atom catalysts (SACs) with unitary active sites hold great promise for realizing high selectivity toward a single product in the CO electroreduction reaction (CORR). However, achieving high Faradaic efficiency (FE) of multielectron products like methane on SACs is still challenging. Herein, we report a pressure-regulating strategy that achieves 83.

Self-protecting CoFeAl-layered double hydroxides enable stable and efficient brine oxidation at 2 A cm.

Low-energy consumption seawater electrolysis at high current density is an effective way for hydrogen production, however the continuous feeding of seawater may result in the accumulation of Cl, leading to severe anode poisoning and corrosion, thereby compromising the activity and stability. Herein, CoFeAl layered double hydroxide anodes with excellent oxygen evolution reaction activity are synthesized and delivered stable catalytic performance for 350 hours at 2 A cm in the presence of 6-fold concentrated seawater. Comprehensive analysis reveals that the Al ions in electrode are etched off by OH during oxygen evolution reaction process, resulting in M vacancies that boost oxygen evolution reaction activity.

Inhibiting Dissolution of Active Sites in 80 °C Alkaline Water Electrolysis by Oxyanion Engineering.

Commercial alkaline water electrolysers typically operate at 80 °C to minimize energy consumption. However, NiFe-based catalysts, considered as one of the most promising candidates for anode, encounter the bottleneck of high solubility at such temperatures. Herein, we discover that the dissolution of NiFe layered double hydroxides (NiFe-LDH) during operation not only leads to degradation of anode itself, but also deactivates cathode for water splitting, resulting in decay of overall electrocatalytic performance.

Dynamic chloride ion adsorption on single iridium atom boosts seawater oxidation catalysis.

Seawater electrolysis offers a renewable, scalable, and economic means for green hydrogen production. However, anode corrosion by Cl pose great challenges for its commercialization. Herein, different from conventional catalysts designed to repel Cl adsorption, we develop an atomic Ir catalyst on cobalt iron layered double hydroxide (Ir/CoFe-LDH) to tailor Cl adsorption and modulate the electronic structure of the Ir active center, thereby establishing a unique Ir-OH/Cl coordination for alkaline seawater electrolysis.

Model-Informed Dose Selection for a Novel Human Immunoglobulin G4 Derived Monoclonal Antibody Targeting Proprotein Convertase Kwashiorkor Type 9: Insights from Population Pharmacokinetics-Pharmacodynamics and Systems Pharmacology.

Monoclonal antibody drugs targeting proprotein convertase kwashiorkor type 9 (PCSK9) have recently demonstrated remarkable success in lipid-lowering therapies. Specifically, antibodies derived from immunoglobulin G1 (IgG1, alirocumab) and IgG2 (evolocumab) have been successfully utilized for this purpose. Recently, a novel recombinant fully human anti-PCSK9 monoclonal antibody, originally derived from IgG4 and designated as SAL003, was developed.

Gas-induced controllable synthesis of the Cu(100) crystal facet for the selective electroreduction of CO to multicarbon products.

Electrocatalytic CO reduction (ECR) to high value-added chemicals is an excellent method to attenuate the impact of greenhouse effect caused by CO. At the same time, multicarbon products (C) get extensive attention in view of their relatively high energy density and market price. At present, Cu is an important metal electrocatalyst to convert CO into multicarbon products ( ethylene, ethanol, and -propanol); however, its poor selectivity impedes its practical application.

Tuning Intermediates Adsorption and C─N Coupling for Efficient Urea Electrosynthesis Via Doping Ni into Cu.

Simultaneous electrochemical reduction of nitrite and carbon dioxide (CO ) under mild reaction conditions offers a new sustainable and low-cost approach for urea synthesis. However, the development of urea electrosynthesis thus far still suffers from low selectivity due to the high energy barrier of CO formation and the subsequent C─N coupling. In this work, a highly active dendritic Cu Ni catalyst is developed to enable the highly selective electrosynthesis of urea from co-reduction of nitrite and CO , reaching a urea Faradaic efficiency (FE) and production rate of 39.

Gay App Use, Sexuality Traits, and High-Risk Sexual Behaviors Among Men Who Have Sex With Men in China: Mediation Analysis.

Background: Gay geosocial networking apps, also known as "gay apps," have gained increasing popularity in the men who have sex with men (MSM) community. Certain sexuality traits and gay app use are both associated with high-risk sexual behaviors among MSM. However, little is known about the underlying mechanism of such relationships.

Model-Informed Dosing Regimen of Ticagrelor in Chinese Patients With Acute Coronary Syndrome.

The exposure to ticagrelor (BRILINTA) is higher in the East Asian population compared with the White population, thus, East Asians have an increased risk of bleeding. We developed a population pharmacokinetic (PopPK) model of ticagrelor based on a randomized 3 × 3 crossover study in healthy subjects. The area under the concentration-time curve (AUC) of Chinese patients with acute coronary syndrome was simulated based on this model.

Pharmacokinetics, safety, and efficacy of GM1 ganglioside in healthy subjects and patients with multiple myeloma: Two dose-escalation studies.

Purpose: This study aimed to assess the pharmacokinetics, safety, and efficacy of GM1 in healthy Chinese subjects and patients with multiple myeloma.

Methods: The data used in this study was derived from two dose-escalation trials: GM1-101, involving 70 healthy subjects, and GM1-201, which included 160 multiple myeloma patients. Population pharmacokinetics (PopPK) analysis was conducted on a subset of 90 participants using a nonlinear mixed-effects approach, and potential covariates were explored quantitatively.

Ru-doped WO enabling efficient hydrogen oxidation reaction in alkaline media.

Developing highly efficient hydrogen oxidation reaction (HOR) electrocatalysts in alkaline media is of great significance for anion exchange membrane fuel cells (AEMFCs). Herein, we report an efficient Ru-doped hexagonal tungsten trioxide (Ru-WO) HOR electrocatalyst through a hydrothermal strategy. The prepared Ru-WO electrocatalyst exhibits enhanced HOR performance with a 6.

Single atomic Ru in TiO boost efficient electrocatalytic water oxidation to hydrogen peroxide.

Electrocatalytic two-electron water oxidation affords a promising approach for distributed production of HO using electricity. However, it suffers from the trade-off between the selectivity and high production rate of HO due to the lack of suitable electrocatalysts. In this study, single atoms of Ru were controllably introduced into titanium dioxide to produce HO through an electrocatalytic two-electron water oxidation reaction.

Nitrite Electroreduction to Ammonia Promoted by Molecular Carbon Dioxide with Near-unity Faradaic Efficiency.

Electrochemical reduction of nitrite (NO ) offers an energy-efficient route for ammonia (NH ) synthesis and reduction of the level of nitrite, which is one of the major pollutants in water. However, the near 100 % Faradaic efficiency (FE) has yet to be achieved due to the complicated reduction route with several intermediates. Here, we report that carbon dioxide (CO ) can enhance the nitrite electroreduction to ammonia on copper nanowire (Cu NW) catalysts.

Iridium Doped Pyrochlore Ruthenates for Efficient and Durable Electrocatalytic Oxygen Evolution in Acidic Media.

Developing highly active, durable, and cost-effective electrocatalysts for the oxygen evolution reaction (OER) is of prime importance in proton exchange membrane (PEM) water electrolysis techniques. Ru-based catalysts have high activities but always suffer from severe fading and dissolution issues, which cannot satisfy the stability demand of PEM. Herein, a series of iridium-doped yttrium ruthenates pyrochlore catalysts is developed, which exhibit better activity and much higher durability than commercial RuO , IrO , and most of the reported Ru or Ir-based OER electrocatalysts.

Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study.

The present study evaluated the safety, pharmacokinetics/pharmacodynamics (PK/PD), and absolute bioavailability (Fabs) of Dex nasal spray in healthy adult subjects, which serves as a bridge for the subsequent study in children. Part 1: a double-blind, placebo-controlled, single ascending dose study was performed on 48 subjects. For 20-/40-μg groups, every 6/2 subjects received either Dex/placebo nasal spray or Dex/placebo injection in two periods.

Long Short-Term Memory Network for Development and Simulation of Warfarin Dosing Model Based on Time Series Anticoagulant Data.

Background: Warfarin is an effective treatment for thromboembolic disease but has a narrow therapeutic index, and dosage can differ tremendously among individuals. The study aimed to develop an individualized international normalized ratio (INR) model based on time series anticoagulant data and simulate individualized warfarin dosing.

Methods: We used a long short-term memory (LSTM) network to develop an individualized INR model based on data from 4,578 follow-up visits, including clinical and genetic factors from 624 patients whom we enrolled in our previous randomized controlled trial.

A pharmacokinetic study to comparatively evaluate the bioequivalence and safety of a humanized recombinant monoclonal antibody targeting human epidermal growth factor receptor-2 with the reference Herceptin in healthy Chinese subjects.

Purpose: This study aimed to compare the safety, tolerability, pharmacokinetics (PK), and bioequivalence of a test humanized recombinant monoclonal antibody targeting human epidermal growth factor receptor-2 (HER-2) with the reference Herceptin®.

Materials And Methods: The trial consisted of two parts (part I and part II). Part I was an open-label, sequential-cohort dose-escalation study, where 16 healthy subjects were either intravenously infused with QLHER2 (test) at single doses escalating from 0.