Proteinuria Is Associated With an Increased Risk of Sudden Cardiac Arrest in the Young Population.

Background: Proteinuria is a risk factor for cardiovascular events, but its prognostic value for sudden cardiac arrest (SCA) in young individuals remains unproven. We aimed to evaluate whether proteinuria in young people is associated with an increased risk of SCA.

Methods And Results: Individuals aged between 20 and 39 years who underwent health screening between 2009 and 2012 in South Korea were included (n=6 891 400).

Recent Advances of Nitrobenzoselenadiazole for Imaging and Therapy.

The development and practical applications of multifunctional organic fluorophores have garnered significant attention in translational research in recent years. Among the fluorophores, nitrobenzodioxazole (NBD) has been widely used in various fields due to its small size and neutral character, both of which are advantageous for biorelated applications. However, NBD presents some limitations, including (1) suboptimal photophysical properties for in vivo applications and (2) its monofunctional nature, which restricts its use in fluorescence-based bioimaging and sensing.

Morphogenic Growth 3D Printing.

Inspired by nature's morphogenesis, a new 3D printing process -growth printing (GP)- takes advantage of a self-propagating curing front to produce 3D polymeric parts following a growth-like development plan. The propagation of the curing front is driven by the exothermic polymerization of dicyclopentadiene (DCPD), which transforms the liquid resin into a stiff polymer as it propagates at 1 mm s. GP is triggered when a heated initiator contacts the uncured liquid resin in an open container.

Pentosan Polysulfate Sodium and Maculopathy in Patients with Interstitial Cystitis: A Systematic Review and Meta-Analysis.

Purpose: Pentosan polysulfate sodium (PPS) is the only pharmacological intervention approved by the US Food and Drug Administration for treating interstitial cystitis (IC) to date. However, PPS may induce an adverse event, maculopathy, which can be a significant challenge. To determine the risk of PPS-induced maculopathy in patients with IC.

Clinical outcome and pattern of care for isolated or incidental serous tubal intraepithelial carcinoma: a multicenter retrospective cohort study.

Objective: Serous tubal intraepithelial carcinoma (STIC), a potential precursor of high-grade serous carcinoma, is associated with subsequent carcinomas development. This study aimed to identify cases of STIC and serous tubal intraepithelial lesions (STIL) and examine clinical outcomes and patterns of care in mutations carriers undergoing risk-reducing salpingo-oophorectomy (RRSO), as well as patients with incidental STIC/STIL after benign gynecologic surgery.

Methods: This retrospective study was conducted at six institutions to examine patients with isolated STIC/STIL.

Unveiling the role of RPS17 and SLC4A1 in diamond-Blackfan Anemia: A zebrafish-based study.

Diamond-Blackfan Anemia (DBA) is a rare congenital disorder characterized by macrocytic anemia, physical abnormalities, and growth delays. Although RPS19 mutations have been more extensively studied in DBA compared to other ribosomal protein genes, the pathological mechanisms of genes such as RPS17 remain largely unexplored. This study aimed to investigate the role of RPS17 haploinsufficiency in DBA, focusing on its downstream effects on erythropoiesis and the involvement of SLC4A1, a critical erythrocyte membrane protein essential for red blood cell stability.

Impaired Endothelial Function in Individuals With Post-Acute Sequelae of COVID-19: Effects of Combined Exercise Training.

Purpose: We investigated the presence of impaired endothelial function in individuals with post-acute sequelae of coronavirus disease-2019 (PASC) compared to healthy individuals and explored the efficacy of combined exercise training in restoring or improving endothelial function in those with PASC.

Methods: Study I was a cross-sectional study which compared endothelial function between individuals with PASC (n = 29, mean age 22.9 ± 3.

Anti-Inflammatory and Pain-Relieving Effects of Arnica Extract Hydrogel Patch in Carrageenan-Induced Inflammation and Hot Plate Pain Models.

(AM), which belongs to the daisy family Asteraceae, has a longstanding traditional use in Europe and North America for pain and inflammation treatment. This study investigates the inhibitory effects of ' extract hydrogel patch (AHP)' on Carrageenan-induced paw edema and hot plate-induced pain models. AHP exhibited transdermal permeability without the occurrence of issues like crystal precipitation.

Increased Mortality Associated with Amiodarone Compared to Other Antiarrhythmic Drugs in New-Onset Atrial Fibrillation.

Antiarrhythmic drugs (AADs) are the primary treatment for maintaining sinus rhythm in patients with atrial fibrillation (AF). While amiodarone is mainly used in patients with structural heart disease, its effects on all-cause mortality compared to other AADs remain unclear. This study utilized nationwide healthcare insurance data involving patients with new-onset AF from 2013 to 2019.

Synthesis of Autotaxin-Inhibiting Lipid Nanoparticles to Regulate Autophagy and Inflammatory Responses in Activated Macrophages.

Background: Autotaxin (ATX), an ENPP2 enzyme, regulates lipid signaling by converting lysophosphatidylcholine to lysophosphatidic acid (LPA). Dysregulation of the ATX/LPA axis promotes inflammation and disease progression. BMP-22, a lipid ATX inhibitor, effectively reduces LPA production.

Development of a Machine Learning-Powered Optimized Lung Allocation System for Maximum Benefits in Lung Transplantation: A Korean National Data.

Background: An ideal lung allocation system should reduce waiting list deaths, improve transplant survival, and ensure equitable organ allocation. This study aimed to develop a novel lung allocation score (LAS) system, the MaxBenefit LAS, to maximize transplant benefits.

Methods: This study retrospectively analyzed data from the Korean Network for Organ Sharing database, including 1,599 lung transplant candidates between September 2009 and December 2020.

3D bioprintable Mg-incorporated hydrogels tailored for regeneration of volumetric muscle loss.

Current therapeutic approaches for volumetric muscle loss (VML) face challenges owing to limited graft availability and insufficient bioactivity. Three-dimensional (3D) bioprinting has become an alternative technology for fabricating native tissue-mimetic grafts, allowing for tailored structures and complex designs. We developed an Mg-incorporated bioink composed of thiolated gelatin (GtnSH) and maleimide-conjugated gelatin (GtnMI) decorated with magnesium peroxide (MgO), referred to as a GtnSH/GtnMI/MgO bioink.

Profile for Brain Disease Research Infrastructure for Data Gathering and Exploration (BRIDGE) Platform.

Brain diseases complexity have necessitated advanced research platforms for better understanding, treatment, and prevention strategies. However, existing brain disease registries face limitations such as incomplete variable sets, lack of standardization, insufficient linkage to external databases, absence of integrated platforms for comprehensive data collection, and lack of continuity. To address these challenges, the Korea National Institute of Health initiated the Brain disease Research Infrastructure for Data Gathering and Exploration (BRIDGE), a national prospective platform designed to overcome the shortcomings of current registries.

Postoperative cholesterol changes as early predictors of breast cancer-related lymphedema: a retrospective cohort study.

Background: Early prediction and management are crucial for treating breast cancer-related lymphedema (BCRL), yet the risk factors remain poorly understood. This study aims to explore the relationship between postoperative changes in serum cholesterol levels and the development of lymphedema.

Methods: This retrospective study analyzed breast cancer patients who underwent surgery between March 2014 and March 2019.

Disproportionality analysis of Raynaud's phenomenon associated with calcitonin gene-related peptide inhibitors using the Food and Drug Administration adverse event reporting system.

Raynaud's phenomenon is a vascular condition characterized by episodic vasoconstriction, and recent reports suggest a potential link between calcitonin gene-related peptide (CGRP) inhibitors, used for migraine treatment, and the onset of this condition. This study evaluated the association between CGRP inhibitors and Raynaud's phenomenon using data from the FDA Adverse Event Reporting System (FAERS). A retrospective analysis of adverse events from the approval year of each drug through August 2023 was conducted.

A novel 11β-HSD1 inhibitor ameliorates liver fibrosis by inhibiting the notch signaling pathway and increasing NK cell population.

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) regulates hepatic glucose output and is implicated in liver fibrosis. We aimed to investigate the anti-fibrotic effect of a novel 11β-HSD1 inhibitor in a thioacetamide (TAA)-induced liver fibrosis mouse model. Mice were administered TAA for 19 weeks and treated with 11β-HSD1 inhibitor for the last 9 weeks.

Hybridizing Fabrications of Gd-CeO Thin Films Prepared by EPD and SILAR-A+ for Solid Electrolytes.

Thin films of gadolinium-doped ceria (GDC) nanoparticles were fabricated as electrolytes for low-temperature solid oxide fuel cells (SOFCs) by combining electrophoretic deposition (EPD) and the successive ionic layer adsorption and reaction-air spray plus (SILAR-A+) method. The CeGdO solid solution was synthesized using hydrothermal (HY) and solid-state (SS) procedures to produce high-quality GDC nanoparticles suitable for EPD fabrication. The crystalline structure, cell parameters, and phases of the GDC products were analyzed using X-ray diffraction.

Association of ulnar variance with primary distal radio-ulnar joint arthritis: a matched case-control study.

Purpose: Knowledge regarding risk factors for primary distal radioulnar joint (DRUJ) arthritis is limited. This study evaluated the association between ulnar variance (UV) and the development of primary DRUJ arthritis in a matched case-control cohort.

Methods: Patients with symptomatic DRUJ arthritis were identified from those attending an orthopaedic outpatient clinic between January 2017 and April 2023.

Clinical practice guidelines for ovarian cancer: an update to the Korean Society of Gynecologic Oncology guidelines.

We updated the Korean Society of Gynecologic Oncology (KSGO) practice guideline for the management of ovarian cancer as version 5.1. The ovarian cancer guideline team of the KSGO published announced the fifth version (version 5.

Preoperative diabetes duration and long-term outcomes in patients with acute myocardial infarction undergoing coronary artery bypass grafting.

Background: The association between preoperative diabetes mellitus (DM) duration and outcomes of coronary artery bypass grafting (CABG) remains unclear. This study aimed to investigate the relationship between DM duration at the time of CABG and long-term outcomes, particularly in patients with acute myocardial infarction.

Methods: Using data from South Korea's National Health Insurance Service database, the study included adult patients who underwent first-time isolated CABG with an acute myocardial infarction diagnosis between 2005 and 2021.

Longitudinal association between hemoglobin and lung function with insights into the incidence of airflow obstruction: an observational study.

Background/aims: Evidence regarding the long-term association between hemoglobin (Hb) levels and lung function in individuals from the general population is scarce. This study aimed to determine the longitudinal association between Hb levels and lung function in a community-based population cohort in South Korea.

Methods: We used linear mixed regression analysis to evaluate the longitudinal associations between Hb levels and lung function parameters, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV), and FEV/FVC.

Prognostic impact of 1-year permanent pacemaker implantation after mitral valve surgery with the Cox-maze procedure.

Objectives: This study aimed to evaluate the prognostic impact of permanent pacemaker (PPM) implantation within the first year after mitral valve (MV) surgery combined with the Cox-maze procedure, focusing on long-term outcomes, including overall mortality, infective endocarditis (IE) and ischaemic stroke.

Methods: We conducted a retrospective cohort study using data from the National Health Insurance Service (NHIS) in South Korea, identifying 10 127 patients who underwent MV surgery with the Cox-maze procedure between 2005 and 2020. Patients were classified into the PPM and non-PPM groups based on PPM implantation within 1 year postoperatively.

Tunable Gas Permeation Behavior through Robust, Freestanding Self-Assembled Metal Nanoparticle Membranes.

Membrane-based gas separation offers a promising alternative route to energy-intensive industrial gas separation processes. Conventional microporous membranes often exhibit low gas selectivities for gases with similar kinetic diameters, primarily due to large pore sizes and reliance on Knudsen selectivity. In this study, we present self-assembled gold nanoparticle (Au NP) membranes that enable molecular gas separation within the kinetic diameter range of small gases such as H, CO, and O.

Current Landscape of Adoptive Cell Therapy and Challenge to Develop "Off-The-Shelf" Therapy for Hepatocellular Carcinoma.

Adoptive cell therapy (ACT) is a type of immunotherapy in which autologous or allogeneic immune cells, such as tumor-infiltrating lymphocytes or engineered lymphocytes, are infused into patients with cancer to eliminate malignant cells. Recently, autologous T cells modified to express a chimeric antigen receptor (CAR) targeting CD19 showed a positive response in clinical studies for hematologic malignancies and have begun to be used in clinical practice. This article discusses the current status and promise of ACT research in hepatocellular carcinoma (HCC), focusing on challenges in off-the-shelf ACT using primary cells or induced pluripotent stem cells (iPSCs) with or without genetic engineering.