Limosilactobacillus fermentum KBL674 Alleviates Vaginal Candidiasis.

Candida albicans (C. albicans) is the primary etiologic agent of vaginal candidiasis. Lactobacillus species are predominant in the vaginal microbiome; they inhibit the development of vaginal candidiasis by producing antimicrobial agents, such as lactic acid and hydrogen peroxide.

The therapeutic effect of DX2 inhibition in nicotine-induced lung cancer progression.

Alternative splicing products of AIMP2 and AIMP2-DX2 (DX2) have been reported to be associated with human lung cancer. In fact, DX2 expression is elevated in human lung cancers, and DX2 transgenic mice also develop lung cancer, in particular small cell lung cancer (SCLC). However, the mechanism by which DX2 is induced during cancer progression has not been clearly elucidated.

Maximization strategies in relationship and career enhances life satisfaction through meaning making among established adults in South Korea.

Background: Choosing a partner and job have long been regarded as important developmental milestones to reach in adulthood. In a collective cultural context with high familial and societal expectations to commit to a relationship and job by age 30, maximizing on such life decisions might potentially harm one's well-being. The literature on maximization-well-being association is complex, and recent research suggests that this relationship might differ by its dimensions and cultural context.

Antiobesity Effects of Subsp. , L. casei 431 on High-Fat Diet-Induced Obese Rats.

Obesity is currently regarded as a global concern, and the key objectives of the global health strategy include its prevention and control. Probiotic supplementation can help achieve these objectives. This study aimed to assess whether a probiotic strain ssp.

Peer network in math anxiety: A longitudinal social network approach.

Regardless of age, math anxiety (i.e., adverse affective reactions in situations involving math) is associated with lower math achievement.

Validation of the Korean Version of Culturally Responsive Experiences in Close Relationships-Short Form.

The authors developed and validated the Korean version of the Experiences in Close Relationships-Short Form (K-ECRR-SF) with the goal of developing a culturally responsive scale. In study 1, a Rasch analysis was conducted on the 36 original items in the ECR-Revised (ECR-R) to select items that best represent anxiety and avoidance subscales by considering cultural equivalence. In study 2, confirmatory factor analysis (CFA) was conducted for the selected 12 items with a different sample.

Perception and Experience of Sexual and Gender Minority Korean Youth in School Counseling.

Unlabelled: To comprehensively explore the school counseling experience of sexual and gender minority (SGM) youths in South Korea, we interviewed 14 SGM youths about their school counseling experience and the climate of their schools toward SGM. Results showed that a hostile school climate and the accessibility, confidentiality, trustworthiness, and LGBTQ competency of school counselors drove the reluctance of these youths to receive school counseling services. Implications for the role of school counseling services for SGM youths were discussed based on the findings of this work and the suggestions offered by the interviewed SGM youths.

Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model.

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective death of motor neurons. Mutations in Cu, Zn-superoxide dismutase (SOD1) causing the gain of its toxic property are the major culprit of familial ALS (fALS). The abnormal SOD1 aggregation in the motor neurons has been suggested as the major pathological hallmark of ALS patients.

Diversity-oriented routes to thiopeptide antibiotics: total synthesis and biological evaluation of micrococcin P2.

We report the first total synthesis of micrococcin P2 (MP2, 1) by a diversity-oriented route that incorporates a number of refinements relative to earlier syntheses. Biological data regarding the activity of 1 against a range of human pathogens are also provided. Furthermore, we disclose a chemical property of MP2 that greatly facilitates medicinal chemistry work in the micrococcin area and describe a method to obtain MP2 by fermentation in .

Using the Theory of Planned Behavior to Predict Korean College Students' Help-Seeking Intention.

When dealing with the mental health concerns of college students, access to professional mental health services is necessary to enable early identification and prevention of severe mental health issues. Accordingly, this study used the theory of planned behavior (TPB) as a theoretical framework to determine the predictors of help-seeking intentions among college students in Korea. The authors developed a TPB questionnaire to measure attitudes, subjective norms, behavioral control, and intentions for seeking help and subsequently validated it via the confirmatory factor analysis (CFA).

South Korea's proactive approach to the COVID-19 global crisis.

This article introduces South Korea's proactive approach in dealing with the COVID-19 pandemic from the mental health perspective at various levels, including national-level policies, medical systems, infrastructures, and mental health professionals, as well as establishing connections and support for citizens. Implications for the internationalization of psychology are discussed. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

The association of stromal antigen 3 (STAG3) sequence variations with spermatogenic impairment in the male Korean population.

The stromal antigen 3 (STAG3) gene, encoding a meiosis-specific cohesin component, is a strong candidate for causing male infertility, but little is known about this gene so far. We identified STAG3 in patients with nonobstructive azoospermia (NOA) and normozoospermia in the Korean population. The coding regions and their intron boundaries of STAG3 were identified in 120 Korean men with spermatogenic impairments and 245 normal controls by using direct sequencing and haplotype analysis.

Global gene expression analysis of cell-free RNA in amniotic fluid from women destined to develop preeclampsia.

Preeclampsia (PE) is a disorder specific to pregnancy characterized by new-onset hypertension and proteinuria after 20 weeks of gestation. There is no definite treatment for PE except delivery of the placenta. The purpose of this study was to elucidate the biological pathways involved in the development of PE and to discover a novel biomarker for PE by performing global gene expression analysis of amniotic fluid cell-free RNA.

Functional analysis of cell-free RNA using mid-trimester amniotic fluid supernatant in pregnancy with the fetal growth restriction.

The prediction and monitoring of fetal growth restriction (FGR) fetuses has become with the use of ultrasound. However, these tools lack the fundamental evidence for the growth of fetus with FGR excluding pathogenic factors.Amniotic fluid samples were obtained from pregnant women for fetal karyotyping and genetic diagnosis at 16 to 19 weeks of gestation.

Sequence variations of the EGR4 gene in Korean men with spermatogenesis impairment.

Background: Egr4 is expressed in primary and secondary spermatocytes in adult mouse testes and has a crucial role in regulating germ cell maturation. The functional loss of Egr4 blocks spermatogenesis, significantly reducing the number of spermatozoa that are produced. In this study, we examined whether EGR4 variants are present in Korean men with impaired spermatogenesis.

Identification of nucleosome assembly protein 1 (NAP1) as an interacting partner of plant ribosomal protein S6 (RPS6) and a positive regulator of rDNA transcription.

The ribosomal protein S6 (RPS6) is a downstream component of the signaling mediated by the target of rapamycin (TOR) kinase that acts as a central regulator of the key metabolic processes, such as protein translation and ribosome biogenesis, in response to various environmental cues. In our previous study, we identified a novel role of plant RPS6, which negatively regulates rDNA transcription, forming a complex with a plant-specific histone deacetylase, AtHD2B. Here we report that the Arabidopsis RPS6 interacts additionally with a histone chaperone, nucleosome assembly protein 1(AtNAP1;1).

Ribosomal protein S6, a target of rapamycin, is involved in the regulation of rRNA genes by possible epigenetic changes in Arabidopsis.

The target of rapamycin (TOR) kinase pathway regulates various biological processes, including translation, synthesis of ribosomal proteins, and transcription of rRNA. The ribosomal protein S6 (RPS6) is one of the well known downstream components of the TOR pathway. Ribosomal proteins have been known to have diverse functions in regulating cellular metabolism as well as protein synthesis.

Possible dual regulatory circuits involving AtS6K1 in the regulation of plant cell cycle and growth.

The role of Arabidopsis S6 Kinase 1 (AtS6K1), a downstream target of TOR kinase, in controlling plant growth and ribosome biogenesis was characterized after generating transgenic plants expressing AtS6K1 under auxin-inducible promoter. Down regulation of selected cell cycle regulatory genes upon auxin treatment was observed in the transgenic plants, confirming the negative regulatory role of AtS6K1 in the plant cell cycle progression reported earlier. Callus tissues established from these transgenic plants grew to larger cell masses with more number of enlarged cells than untransformed control, demonstrating functional implication of AtS6K1 in the control of plant cell size.

An atypical soybean leucine-rich repeat receptor-like kinase, GmLRK1, may be involved in the regulation of cell elongation.

A leucine-rich repeat receptor-like kinase (LRR-RLK) encoded by one of the genes highly expressed in a specific stage of soybean seed development, referred to as GmLRK1, was identified and characterized. Examination of its kinase domain indicated that GmLRK1 may be a catalytically inactive atypical receptor kinase. An autophosphorylation assay confirmed that GmLRK1 is incapable of autophosphorylation in vitro.