Publications by authors named "Yun Jee Lee"
Constitutive androstane receptor mediates PCB-induced disruption of retinoid homeostasis.
Toxicol Appl Pharmacol
October 2019
Article Synopsis
- Environmental exposure to PCBs, specifically PCB153, disrupts retinoid (vitamin A) homeostasis, which may increase metabolic disease risk.
- The study identifies the constitutive androstane receptor (CAR) as a key mediator in this disruption, particularly through the activation of liver enzymes that affect retinoid metabolism.
- Dietary retinoids can reverse the changes caused by PCB153, suggesting that CAR activation and subsequent retinoid imbalance could play a significant role in the obesogenic effects of PCBs.