Regulation of Betaine Homocysteine Methyltransferase by Liver Receptor Homolog-1 in the Methionine Cycle.

Betaine-homocysteine S-methyltransferase (BHMT) is one of the most abundant proteins in the liver and regulates homocysteine metabolism. However, the molecular mechanisms underlying transcription have not yet been elucidated. This study aimed to assess the molecular mechanisms underlying transcription and the effect of BHMT deficiency on metabolic functions in the liver mediated by liver receptor homolog-1 (LRH-1).

Theoretical efficiency limit of diffractive input couplers in augmented reality waveguides.

Considerable efforts have been devoted to augmented reality (AR) displays to enable the immersive user experience in the wearable glasses form factor. Transparent waveguide combiners offer a compact solution to guide light from the microdisplay to the front of eyes while maintaining the see-through optical path to view the real world simultaneously. To deliver a realistic virtual image with low power consumption, the waveguide combiners need to have high efficiency and good image quality.

RPL27 contributes to colorectal cancer proliferation and stemness via PLK1 signaling.

Although expression of ribosomal protein L27 (RPL27) is upregulated in clinical colorectal cancer (CRC) tissue, to the best of our knowledge, the oncogenic role of RPL27 has not yet been defined. The present study aimed to investigate whether targeting RPL27 could alter CRC progression and determine whether RPL27 gains an extra‑ribosomal function during CRC development. Human CRC cell lines HCT116 and HT29 were transfected with RPL27‑specific small interfering RNA and proliferation was assessed and using proliferation assays, fluorescence‑activated cell sorting (FACS) and a xenograft mouse model.

Clinical Characteristics of TZAP (ZBTB48) in Hepatocellular Carcinomas from Tissue, Cell Line, and TCGA.

: ZBTB48 is a telomere-related protein that has been renamed telomeric zinc finger-associated protein (TZAP). It favorably binds to elongated telomeres to regulate their appropriate length. However, TZAP expression has not been investigated in hepatocellular carcinomas (HCC).

Loss of phospholipase Cγ1 suppresses hepatocellular carcinogenesis through blockade of STAT3-mediated cancer development.

Phospholipase C gamma 1 (PLCγ1) plays an oncogenic role in several cancers, alongside its usual physiological roles. Despite studies aimed at identifying the effect of PLCγ1 on tumors, the pathogenic role of PLCγ1 in the tumorigenesis and development of hepatocellular carcinoma (HCC) remains unknown. To investigate the function of PLCγ1 in HCC, we generated hepatocyte-specific PLCγ1 conditional knockout (PLCγ1 ; Alb-Cre) mice and induced HCC with diethylnitrosamine (DEN).

Towards compact and snapshot channeled Mueller matrix imaging.

A polarization transformation can be fully described by a 4 × 4 matrix, known as the Mueller matrix. To fully image an object's polarization response, one needs to compute the Mueller matrix at each pixel of the image. Standard divison-of-time Mueller matrix imaging, because of its sequential nature, is ill-suited to applications requiring immediate and real-time imaging and is also bulky owing to multiple moving parts.

Compensator design for polarization state management in waveguide displays based on polarization volume gratings.

In this work, we focus on the polarization state management in optical devices using optical elements based on circular polarization. As an example, we point out the issue in a waveguide display using circular polarization optical elements as input/output couplers, where the polarization state of the light can change as it propagates in the waveguide due to total internal reflection (TIR). This has a negative effect on the waveguide output coupler efficiency, image uniformity, and the polarization multiplexing capability.

Targeting CALM2 Inhibits Hepatocellular Carcinoma Growth and Metastasis by Suppressing E2F5-mediated Cell Cycle Progression.

Background/aim: The aim of this study was to reveal the novel roles of calmodulin 2 (CALM2) in hepatocellular carcinoma (HCC) progression.

Materials And Methods: The effects of knockdown of CALM2 expression by siRNA were investigated using various experimental approaches in both cellular and molecular levels.

Results: Silencing of CALM2 inhibited HCC cell proliferation and colony formation through induction of apoptosis.

Clinicopathological Characteristics of TZAP Expression in Colorectal Cancers.

Purpose: The zinc finger protein, ZBTB48, is a telomere-associated protein. It was renamed as telomeric zinc finger-associated protein (TZAP) binding to elongated telomeres. However, its expression level was not measured in cancers.

Histone deacetylase inhibitor CG200745 ameliorates high-fat diet-induced hypertension via inhibition of angiotensin II production.

Obesity is growing rapidly worldwide due to consumption of westernized diet and lack of exercise. Obesity is one of the major risk factors of hypertension. The novel histone deacetylase (HDAC) inhibitor CG200745 was originally developed to treat various cancers.

Improving near-eye display resolution by polarization multiplexing.

We present here an optical approach to boost the apparent pixel density by utilizing the superimposition of two shifted-pixel grids generated by a Pancharatnam-Berry deflector (PBD). The content of the two shifted pixel grids are presented to the observer's eye simultaneously using a polarization-multiplexing method. Considering the compact and lightweight nature of PBD, this approach has potential applications in near-eye display systems.

Disruption of the Myc-PDE4B regulatory circuitry impairs B-cell lymphoma survival.

A large body of evidence suggests that B-cell lymphomas with enhanced Myc expression are associated with an aggressive phenotype and poor prognosis, which makes Myc a compelling therapeutic target. Phosphodiesterase 4B (PDE4B), a main hydrolyzer of cyclic AMP (cAMP) in B cells, was shown to be involved in cell survival and drug resistance in diffuse large B cell lymphomas (DLBCL). However, the interrelationship between Myc and PDE4B remains unclear.

Stretchable, flexible, rollable, and adherable polarization volume grating film.

Volume Bragg gratings (VBGs) have many applications, including filters, wavelength multiplexing devices, and see-through displays. As a kind of VBGs, polarization volume gratings (PVGs) based on liquid crystal polymer have the advantages of nearly 100% efficiency, large deflection angle, and high polarization selectivity. However, previous reports regarding PVGs did not address high efficiency, tunable periodicity, and flexibility.

Photo-responsive dye-doped liquid crystals for smart windows.

An electric field drives most dye-doped liquid crystal devices. Here, we demonstrate a new photo-responsive dye-doped self-organized cholesteric liquid crystal device. Upon UV or blue light exposure, the helical twisting power of the chiral azobenzene changes because of the trans-cis isomerization.

Fabrication of Pancharatnam-Berry phase optical elements with highly stable polarization holography.

Polarization-dependent diffraction based on Pancharatnam-Berry phase optical elements (PBOEs) offers considerable benefits compared to conventional metasurfaces, such as negligible absorption, nearly 100% diffraction efficiency and an inexpensive fabrication process. Polarization holography is a simple way to fabricate PBOEs, which entails the interference of beams with different polarizations to generate a spatial-varying polarization field. Thus, the quality of recorded PBOEs manifests high sensitivity to the length change and phase shift between polarized beams, usually caused by environmental vibration and air flow.

Polarization-independent Pancharatnam-Berry phase lens system.

The conventional liquid crystal-based Pancharatnam-Berry (PB) phase lens exhibits distinct polarization selectivity, manifesting opposite optical power to circularly polarized light with opposite handedness. Here, a polarization-independent liquid crystal PB lens system is theoretically predicted and experimentally verified. Such a lens system consists of at least four PB lenses, with specific distances in between them.

High-resolution additive light field near-eye display by switchable Pancharatnam-Berry phase lenses: errata.

We correct a typo in the system parameter. The size of monocular eyebox is corrected to be 16mm (W) by 16mm (H).

Foveated imaging for near-eye displays.

The angular resolution of current near-eye display devices is still far below human-eye acuity. How to achieve retina-level resolution while keeping wide field-of-view (FOV) remains a great challenge. In this work, we demonstrate a multi-resolution foveated display with two display panels and an optical combiner.

Polarization-multiplexed multiplane display.

We demonstrate a polarization-multiplexed multiplane display system for near-eye applications. A polarization-sensitive Pancharatnam-Berry phase lens is implemented to generate two focal depths simultaneously. A spatial polarization modulator is utilized to direct the two images to designated focal planes.

Switchable Pancharatnam-Berry microlens array with nano-imprinted liquid crystal alignment.

We report a rapid nano-imprinting technique to pattern the liquid crystal alignment of a Pancharatnam-Berry phase microlens array. Through implementing a single-side aligned cell, we demonstrate a switchable microlens array with fast response time and low operation voltage. Further investigation of focusing property as well as imaging capability ensure the good quality of the microlens array.

LY3009120, a pan-Raf kinase inhibitor, inhibits adipogenesis of 3T3-L1 cells by controlling the expression and phosphorylation of C/EBP-α, PPAR-γ, STAT‑3, FAS, ACC, perilipin A, and AMPK.

Excessive preadipocyte differentiation/adipogenesis is closely linked to the development of obesity. LY3009120 is a pan‑Raf kinase inhibitor and is known for its anticancer activities. In the present study, the effect of LY3009120 on 3T3‑L1 cell adipogenesis was investigated.