Cyclosporin A suppresses lipopolysaccharide induced matrix metalloproteinases activities in the co-culture of human gingival fibroblasts and monocyte cell line THP-1.

Cyclosporine-A (CsA) is a widely used immunosuppressant. In this study, we explore the pathway through which CsA suppressed the lipopolysaccharide (P.g-LPS)-induced increase in matrix metalloproteinase (MMP) activities in co-cultured human gingival fibroblasts (HGFs) and THP-1 monocytes.

The Pros1/Tyro3 axis protects against periodontitis by modulating STAT/SOCS signalling.

Periodontitis, an oral inflammatory disease caused by periodontal pathogen infection, is the most prevalent chronic inflammatory disease and a major burden on healthcare. The TAM receptor tyrosine kinases (Tyro3, Axl and Mertk) and their ligands (Gas6 and Pros1) play a pivotal role in the resolution of inflammation and have been associated with chronic inflammatory and autoimmune diseases. In this study, we evaluated the effects of exogenous Pros1 in in vitro and in vivo models of periodontitis.

Deletion of C9orf53 promotes the growth of head and neck squamous cell carcinoma and is associated with poor prognosis of patients with head and neck squamous cell carcinoma.

Head and neck squamous cell carcinoma (HNSCC) is the fifth most common carcinoma worldwide, and accounts for ~600,000 new cases every year. The information on the molecular carcinogenesis of HNSCC is very limited. In the present study, the role of C9orf53 in HNSCC was investigated.

A novel videographic method for quantitatively tracking vibrissal motor recovery following facial nerve injuries in rats.

Background: Previous studies of vibrissal movements employ either optoelectronic recording techniques in the head fixed rodent, or videographic recordings in freely moving animals. However, both approaches have shortcomings for quantitatively tracking the process of vibrissal motor recovery.

New Method: A critical feature of our videographic method is to measure tagged vibrissae movements while leaving all others intact in body restrained rats without head fixation.

The role of large-conductance, calcium-activated potassium channels in a rat model of trigeminal neuropathic pain.

Background: Trigeminal neuralgia is a disorder of paroxysmal and severely disabling facial pain and continues to be a real therapeutic challenge. At present there are few effective drugs. Here the aim of this study was to investigate the role of BKCa channels in trigeminal neuropathic pain.

Serum cyclophilin A concentrations in renal transplant recipients receiving cyclosporine A: clinical implications for gingival overgrowth.

Objective: The aim of this study was to investigate the clinical factors in relation to the cyclosporine A (CsA) induced gingival overgrowth (GO).

Study Design: Seventy-three participants were assigned as GO+ and GO-. Factors including demographic, pharmacological, gingival variables and the serum cyclophilin A (CyPA) concentration were analyzed.

Synchronous bilateral pleomorphic adenomas of the parotid gland.

Bilateral pleomorphic adenomas of the parotid gland are extremely rare, accounting for less than 0.2% of all parotid gland tumors. We present a rare case of a patient with synchronous bilateral pleomorphic adenomas of the parotid gland.

Periosteal osteosarcoma of the mandible: case report and review of the literature.

Purpose: Periosteal osteosarcoma is an intermediate-grade chondroblastic osteosarcoma, accounting for less than 2% of all osteosarcomas and it occurs extremely rarely in the jaws. We present a rare case of mandibular periosteal osteosarcoma.

Patients And Methods: A 39-year-old man presented with a four months history of a firm swelling of the mental region.

[BK(Ca) channel agonist NS1619 and Kv channel antagonist 4-AP on the facial mechanical pain threshold in a rat model of chronic constriction injury of the infraorbital nerve].

Trigeminal neuralgia is a paroxysmal disorder with severely disabling facial pain and thus continues to be a real therapeutic challenge. At present there are few effective drugs for treatment of this pain. The present study was aimed to explore the involvement of BK(Ca) channels and Kv channels in the mechanical allodynia in a rat model of trigeminal neuropathic pain.

Castleman's disease of the neck: report of 4 cases with unusual presentations.

Purpose: Most of the previously reported cases of Castleman’s disease (CD) in the neck were of the hyaline vascular type and the most common sign was an asymptomatic neck mass. To achieve a more general recognition of CD in the neck, we present four cases of CD in the neck with unusual presentations.

Patients And Methods: We describe four cases of CD in the neck with unusual clinical manifestations, different histopathologic subtypes and discuss the problems arising in their clinical findings.

[Connection of trigeminal nerve and facial nerve branches and its clinical significance].

In recent years, many anatomical researches have showed that there are common and extensive connections between the trigeminal nerve and the facial nerve.They are briefly outlined as follows: (1) The infraorbital nerve communicates with buccal branch of the facial nerve. (2) The auriculotemporal nerve of the trigeminal nerve communicates with the buccal, zygomatic,temporal branches and the upper divisions of the facial nerve.

[The neuromuscular toxicity and clinical application of adriamycin].

Adriamycin (doxorubicin) is commonly used in the treatment of malignant tumours. In recent years,retrograde adriamycin sensory ganglionectomy has been used in treatment of trigeminal neuralgia and has obtained good therapeutic effect. The mechanism of action, particularly, of the toxic effects with different medication methods and choice of doses for muscle cells and nerve cells is still unclear.

[The expression and significance of osteopontin and its receptor CD44v6 in oral squamous carcinoma].

Objective: To study the clinical significance of osteopontin (OPN) and its receptor CD44v6 expression in oral squamous cell carcinoma (OSCC).

Methods: OPN and CD44v6 expression were examined in OSCC (n=59) and normal oral mucosa (n=12) by EnVision method, the staining-grade were quantitatively studied by multiple functional image analyzer. Their expression grade of different clinical and pathological index were statistically studied.

[Local drug injection for the treatment of trigeminal neuralgia].

Trigeminal neuralgia is the most common facial pain syndrome,which remains a difficult condition to manage due to lack of knowledge on pathophysiological mechanisms. Local drug injection is a minimally invasive and useful technique to manage trigeminal neuralgia, with a high success rate and low incidence of morbidity. Although a large number of drugs have been used to treat trigeminal neuralgia, there still remains a great challenge to reduce the recurrent rates and complications both intra- or post- injections.

[Microvessel density and expression of vascular endothelial growth factor in adenoid cystic carcinoma of salivary gland].

Objective: To discern whether the microvessel density (MVD) and the expression of vascular endothelial growth factor (VEGF) could be prognostic indicators for the metastasis and survival of patients with SACC after radical surgery.

Methods: After the follow-up of 31 primary patients with SACC treated with radical surgeries for at least 60 months, the paraffin-bedded sections of the those patients were stained immunohistochemically with anti-CD34-McAb and anti-VEGF-McAb, respectively. Subsequently, two pathologists double-blindly evaluated the sections stained with anti-CD34-McAb to determine the MVD values individually, as well as, measured the sections stained with the ani-VEGF-McAb to determine the OD values.