Background: The World Health Organization has set a global strategy to eliminate cervical cancer, emphasizing the need for cervical cancer screening coverage to reach 70%. In response, China has developed an action plan to accelerate the elimination of cervical cancer, with Hubei province implementing China's first provincial full-coverage screening program using an artificial intelligence (AI) and cloud-based diagnostic system.
Objective: This study aimed to evaluate the performance of AI technology in this full-coverage screening program.
Background: Administration of olanzapine (OLA) is closely associated with obesity and glycolipid abnormalities in patients with schizophrenia (SCZ), although the exact molecular mecha- nisms remain elusive.
Objective: We conducted comprehensive animal and molecular experiments to elucidate the mecha- nisms underlying OLA-induced weight gain.
Methods: We investigated the mechanisms of OLA-induced adipogenesis and lipid storage by em- ploying a real-time ATP production rate assay, glucose uptake test, and reactive oxygen species (ROS) detection in 3T3-L1 cells and AMSCs.
Curr Alzheimer Res
October 2024
Alzheimer's disease (AD) is the most common type of dementia among middle-aged and elderly individuals. Accelerating the prevention and treatment of AD has become an urgent problem. New technology including Computer-aided drug design (CADD) can effectively reduce the medication cost for patients with AD, reduce the cost of living, and improve the quality of life of patients, providing new ideas for treating AD.
View Article and Find Full Text PDFThis study aimed to analyze the characteristics and risk factors associated with casual sexual behavior among sexually active college students and to contribute to AIDS prevention and control efforts among this demographic. A cross-sectional survey was conducted using a stratified cluster sampling technique. Self-reported sexually active college students were selected as respondents from 11 cities in Zhejiang Province from October 8 to November 30, 2018.
View Article and Find Full Text PDFIt is a challenge for the traditional affinity methods to capture transient interactions of enzyme-post-translational modification (PTM) substrates in vivo. Herein we presented a strategy termed proximity labeling-based orthogonal trap approach (ProLORT), relying upon APEX2-catalysed proximity labeling and an orthogonal trap pipeline as well as quantitative proteomics to directly investigate the transient interactome of enzyme-PTM substrates in living cells. As a proof of concept, ProLORT allows for robust evaluation of a known HDAC8 substrate, histone H3K9ac.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is a degenerative neurological disorder. Recent studies have indicated that histone deacetylases (HDACs) are among the most prominent epigenetic therapy targets and that HDAC inhibitors have therapeutic effects on AD. Here, we identified sodium valproate (VPA), a pan-HDAC inhibitor, and WT161, a novel HDAC6 selective inhibitor, as potential therapeutic agents for AD.
View Article and Find Full Text PDFSome disinfection by-products (DBPs) in drinking water present a potential safety concern. This study focuses on the elements influencing DBPs formation. A total of 120 water samples were collected from 10 different drinking water facilities spanning 5 counties within Huzhou, Zhejiang Province, China.
View Article and Find Full Text PDFMelanoma cells were more resistant to ferroptosis with still poor therapy outcomes. Sensitizing melanoma cell to the ferroptosis inducer was a crucial strategy for treatment of melanoma. In the present study, 2,2'-di-pyridylketone hydrazone dithiocarbamate s-butyric acid (DpdtbA) displayed superior inhibitory activity than ferroptosis inducer Erastin in melanoma cells, which prompt us to explore the underlying mechanism.
View Article and Find Full Text PDFConsidering that typically more than two pin diodes or other tunable elements are required in the unit cell of polarization-insensitive reconfigurable metasurfaces (RMs), this paper proposes a new approach to design a polarization-insensitive RM unit using only one VO chip. A polarization-insensitive phase-modulated metasurface (PMM) using single VO chip is presented. The surface layer is composed of an outer ring and an inner cross, with a VO chip loaded at the connection of the cross.
View Article and Find Full Text PDFCrude oil pipelines are considered as the lifelines of energy industry. However, accidents of the pipelines can lead to severe public health and environmental concerns, in which greenhouse gas (GHG) emissions, primarily methane, are frequently overlooked. While previous studies examined fugitive emissions in normal operation of crude oil pipelines, emissions resulting from accidents were typically managed separately and were therefore not included in the emission account of oil systems.
View Article and Find Full Text PDFIEEE Trans Image Process
August 2023
There are demographic biases present in current facial recognition (FR) models. To measure these biases across different ethnic and gender subgroups, we introduce our Balanced Faces in the Wild (BFW) dataset. This dataset allows for the characterization of FR performance per subgroup.
View Article and Find Full Text PDFTau protein hyperphosphorylation and formation of intracellular neurofibrillary tangles (NFTs) are one of the histopathological hallmarks of Alzheimer's disease (AD) and positively correlated with the severity of AD symptoms. NFTs contain a large number of metal ions that play an important role in regulating tau protein phosphorylation and AD progression. Extracellular tau induces primary phagocytosis of stressed neurons and neuronal loss by activating microglia.
View Article and Find Full Text PDFJ Neural Transm (Vienna)
October 2023
Although depressive symptoms are common in PD, few studies investigated sex and age differences in depressive symptoms. Our study aimed to explore the sex and age differences in the clinical correlates of depressive symptoms in patients with PD. 210 PD patients aged 50-80 were recruited.
View Article and Find Full Text PDFIEEE Trans Pattern Anal Mach Intell
September 2023
Efficient image super-resolution (SR) has witnessed rapid progress thanks to novel lightweight architectures or model compression techniques (e.g., neural architecture search and knowledge distillation).
View Article and Find Full Text PDFCalliptamus barbarus Costa is a species in genus Calliptamus, belonging to the Calliptaminae, Acrididae, Orthoptera. In the present study, the mitogenome of C. barbarous was determined and annotated to better identify C.
View Article and Find Full Text PDFK-means is a fundamental clustering algorithm widely used in both academic and industrial applications. Its popularity can be attributed to its simplicity and efficiency. Studies show the equivalence of K-means to principal component analysis, non-negative matrix factorization, and spectral clustering.
View Article and Find Full Text PDFIEEE Trans Image Process
December 2022
Human motion segmentation (HMS) aims to segment a long human action video into a bunch of short and meaningful action clips. Existing supervised learning approaches need a large amount of training data which may be costly in real-world scenario, while most unsupervised clustering methods cannot fully explore the temporal correlations among human motions and hard to achieve promising performances. In our paper, we design a novel unsupervised framework, called Velocity-Sensitive Dual-Side Auto-Encoder (VSDA), for HMS task.
View Article and Find Full Text PDFPoly(ADP-ribose) polymerase 1 (PARP1) is essential for the progression of several types of cancers. However, whether and how PARP1 is stabilized to promote genomic stability in triple-negative breast cancer (TNBC) remains unknown. Here, we demonstrated that the deubiquitinase USP15 interacts with and deubiquitinates PARP1 to promote its stability, thereby stimulating DNA repair, genomic stability and TNBC cell proliferation.
View Article and Find Full Text PDFBackground And Aim: Chuanxiong Renshen decoction (CRD) is a traditional Chinese medicine compound used to treat Alzheimer's disease (AD). However, the effects and active ingredients of CRD and its mechanism have not been clarified. We aimed to determine the neuroprotective effects of CRD in a triple-transgenic mouse model of AD (3 × Tg-AD) and investigate the possible active ingredients and their mechanisms.
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant tumors with a poor prognosis. Type X collagen α 1 chain (COL10A1), a member of the collagen family, is a gene associated with the progression of a variety of human tumors, but the specific function and molecular mechanism of COL10A1 in pancreatic cancer remain unclear. Our study found that COL10A1 is highly expressed in pancreatic cancer cells and tissues, and its high expression is related to poor prognosis and some clinicopathological features, such as tumor size and differentiation.
View Article and Find Full Text PDFBMC Oral Health
November 2022
Background: Hereditary gingival fibromatosis (HGF) is characterized by sub-epithelial fibromatosis of keratinized gingiva resulting in a fibrotic enlargement of keratinized gingiva. The treatment choice is gingivectomy, which can be performed with an internal or external bevel incision conventionally. However, both techniques can hardly resume the natural status of gingiva, and have a certain recurrence rate, especially in the cases which have limited width of attached gingiva.
View Article and Find Full Text PDFSemi-supervised domain adaptation (SSDA) is quite a challenging problem requiring methods to overcome both 1) overfitting towards poorly annotated data and 2) distribution shift across domains. Unfortunately, a simple combination of domain adaptation (DA) and semi-supervised learning (SSL) methods often fail to address such two objects because of training data bias towards labeled samples. In this paper, we introduce an adaptive structure learning method to regularize the cooperation of SSL and DA.
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