Publications by authors named "Yun C Leung"
Background: Arginine deprivation was previously shown to inhibit retinoblastoma cell proliferation and induce cell death in vitro. However, the mechanisms by which retinoblastoma cells respond to arginine deprivation remain to be elucidated.
Methods: The human-derived retinoblastoma cell lines Y79 and WERI-Rb-1 were subjected to arginine depletion, and the effects on inhibiting cell growth and survival were evaluated.
Article Synopsis
- - The study explores how stereoselective fluorination can change the properties of a cyclic tetrapeptide that contains RGD.
- - It evaluates three main outcomes: how fluorination affects the efficiency of peptide cyclization, the adjustment of molecular shape, and the influence on the biological activity of the cyclic peptides.
- - Results indicate that fluorination significantly impacts all three aspects, leading to important insights in peptide design.
Article Synopsis
- Backbone-extended amino acids could revolutionize peptide and protein science if their structures can be controlled.
- The study focuses on creating δ-amino acids with three C-F bonds along their backbone using various synthetic methods.
- The researchers found that different diastereoisomers of these fluorinated amino acids have unique shapes in solution, making them potentially useful as customizable building blocks for peptide development.
Pregestational diabetes is highly associated with an increased risk of birth defects. However, factors that can increase or reduce the expressivity and penetrance of malformations in pregnancies in women with diabetes remain poorly identified. All- retinoic acid (RA) plays crucial roles in embryogenesis.
View Article and Find Full Text PDFFlagellar export chaperone FliS prevents premature polymerization of flagellins and is critical for flagellar assembly and bacterial colonization. Previously, a yeast 2-hybrid study identified various FliS-associated proteins in Helicobacter pylori, but the implications of these interactions are not known. Here we demonstrate the biophysical interaction of FliS (HP0753) and the uncharacterized protein HP1076 from H.
View Article and Find Full Text PDFWe have developed a dual expression system for the simultaneous overexpression of two proteins in Bacillus subtilis. Two candidate genes, xylanase (xynA) and glucanase (bglS) from B. subtilis strain 168, which were engineered with independent Shine-Dalgarno (SD) sequences, were cloned in tandem into a transfer vector, which was then transformed into B.
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