Prenatal diagnosis of maternal serum from mothers carrying β-thalassemic fetus.

Background: This study focuses on the discovery of protein biomarkers from the maternal serum of β-thalassemic trait mothers carrying the normal fetus and β-thalassemic major fetus.

Methods: Serum samples from β-thalassemic trait mothers carrying major (N = 5) and normal fetuses (N = 5) were studied. The IVS1-5 thalassemia mutation was common among β-thalassemic trait mothers who were carrying a homozygous β-thalassemic fetus (IVS1-5/ IVS1-5 mutation) or a normal fetus (no mutation).

Antioxidant Activity and Oxidative Stress Status in Maternal Serum of β-thalassemic Mothers Carrying β-thalassemic Major and Normal Fetuses.

β-thalassemia is a genetic disorder characterized by reduction or absence of β-globin chain with mutations in both copies (β-thalassemia major) or in one copy (β-thalassemia minor). Pregnancies in β- thalassemic carrier women are considered symptom free but have risk of inheriting β-thalassemic fetuses. Current study was designed to compare oxidative stress and antioxidants status in maternal serum from β-thalassemic minor mothers having β-thalassemic major and normal fetuses.

Nephroprotective effects of b-carotene on ACE gene expression, oxidative stress and antioxidant status in thioacetamide induced renal toxicity in rats.

β -carotene is one of carotenoid natural pigments, which are produced by plants and are accountable for the bright colors of various fruits and vegetables. These pigments have been widely studied for their ability to prevent chronic diseases and toxicities. This study was designed to evaluate the effects of β-carotene on angiotensin converting enzyme (ACE) gene expression, oxidative stress and antioxidant status in thioacetamide induced renal toxicity.

Effects of curcumin on angiotensin-converting enzyme gene expression, oxidative stress and anti-oxidant status in thioacetamide-induced hepatotoxicity.

Introduction: This study aimed to evaluate the protective effects of curcumin on angiotensin-converting enzyme (ACE) gene expression, oxidative stress and anti-oxidant status in thioacetamide (TAA)-induced hepatotoxicity in rats.

Materials And Methods: Total 32 albino Wistar rats (male, 200-250 g) were divided into six groups (n=8). Group 1: untreated controls; Group 2: received TAA (200 mg/kg body weight (b.