Publications by authors named "Yuming Qi"
Article Synopsis
- The liver's biotransformation process can change nanoparticles' surface chemistry, affecting their ability to function and target specific cells.
- The study found that switching the bond in nanoparticles from gold-sulfur (Au-S) to gold-selenium (Au-Se) improved their targeting efficiency to liver cells by 15-fold and altered their transport behaviors in the liver.
- By enhancing the targeting of nanoparticles to liver tumors and reducing dissociation of targeting ligands, this research provides new insights and strategies for designing nanomedicines that can effectively navigate liver biotransformation.
Noninvasive fluorescence imaging of renal function is a valuable technique for understanding kidney disease progression and the development of renal medicine. This technique requires sensitive imaging probes for reporting renal dysfunction accurately at early stage. Herein, a molecularly engineered imaging probe (800CW-PEG-COOH) was synthesized by simply PEGylating conventional near-infrared fluorophore IRDye800CW with NH-PEG-COOH (molecular weight ∼2100 Da) for early detection and staging of renal dysfunction through noninvasive real-time kidney imaging.
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- Renal clearable nanoparticles can effectively eliminate from the body through the kidneys, preventing harmful accumulation, but their interactions with other organs like the liver are still not fully understood.
- This study focused on a specific type of nanoparticle (800CW-GS-Au) that, despite showing minimal liver accumulation, underwent modifications due to liver interactions, which could be detected in urine.
- The findings suggest a way to noninvasively measure liver glutathione levels through urine analysis, enhancing understanding of nanoparticle transport and paving the way for new diagnostic methods.
Understanding the transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of nanoparticles plays a key role in controlling their transport behaviors due to the existence of various physiological size thresholds within the body and size-dependent nano-bio interactions. Encouraged by the evolving discoveries of nanoparticle-size-dependent biological effects, we believe that it is necessary to systematically summarize the size-scaling laws of nanoparticle transport .
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- Organelles play a crucial role in cellular processes, and understanding how targeting them can affect anti-tumor activity is challenging.
- The study focused on synthesizing naphthalimide derivatives modified with either amide or acylhydrazine, finding that some amide variants showed higher cytotoxicity than their acylhydrazine counterparts.
- Through fluorescence imaging and other analyses, it was determined that targeting the nucleus enhances cytotoxic effects by improving DNA binding and causing cell cycle arrest in the S phase, suggesting pathways for future anti-tumor drug development.
Phosphate and aluminate electrolytes were used to prepare plasma electrolytic oxidation (PEO) coatings on 6061 aluminum alloy. The surface and cross-section microstructure, element distribution, and phase composition of the PEO coatings were characterized by SEM, EDS, XPS, and XRD. The friction and wear properties were evaluated by pin-on-disk sliding tests under dry conditions.
View Article and Find Full Text PDFThe objectives of this study were to reduce the corrosion rate and increase the cytocompatibility of AZ31 Mg alloy. Two coatings were considered. One coating contained MgO (MAO/AZ31).
View Article and Find Full Text PDFAn unconstrained monitoring method for a driver's heartbeat is investigated in this paper. Signal measurement was carried out by using pressure sensors array. Due to the inevitable changes of posture during driving, the monitoring place for heartbeat measurement needs to be adjusted accordingly.
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