Publications by authors named "Yumiko Sugishima"
Biochim Biophys Acta
July 2009
Article Synopsis
- TAK1 is a key kinase involved in regulating various signaling pathways related to cytokines and immune receptors.
- Recent research revealed that TNF-alpha can cause the internalization of EGFR through a TAK1-p38alpha pathway, temporarily suppressing EGFR activity.
- The study found that when EGFR is activated, it phosphorylates TAB1 and TAB2; however, the phosphorylation of TAB1 is inhibited by p38alpha, affecting the cells' response to TNF-alpha and reducing NF-kappaB activation.
