Publications by authors named "Yumiko Suenaga"
Background: Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease. High-density lipoproteins (HDLs) exert anti-atherogenic effects, even on cholesterol efflux capacity (CEC). The HDL proteome is reportedly altered in patients with coronary artery disease.
View Article and Find Full Text PDFBackground And Aims: High density lipoprotein (HDL) exerts an anti-atherosclerotic effect via reverse cholesterol transport (RCT). Several phases of RCT are transcriptionally controlled by Liver X receptors (Lxrs). Although macrophage Lxrs reportedly promote RCT, it is still uncertain whether hepatic Lxrs affect RCT in vivo.
View Article and Find Full Text PDFAim: Improving cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) has been regarded as a novel target for preventing cardiovascular disease. HDL reportedly has antioxidant properties which may contribute to its functions. We investigated changes in CEC with intake of the Japan Diet (JD) recommended by the Japan Atherosclerosis Society and the relationship of these changes to serum antioxidant concentrations.
View Article and Find Full Text PDFArticle Synopsis
- The study presents a method using a surface plasmon resonance (SPR) biosensor to assess how effectively different inhibitors prevent the breakdown of collagen IV by the enzyme cathepsin B.
- SPR signal changes showed that higher concentrations of inhibitors led to decreased enzyme activity, with a specific order of effectiveness for each inhibitor.
- The findings indicate that CA074 and Z-Phe-Phe-FMK primarily inhibit exopeptidase activity, while leupeptin is a stronger inhibitor of endopeptidase activity in cathepsin B.