Publications by authors named "Yumiko Hori-Hirose"
JNCI Cancer Spectr
November 2024
Article Synopsis
- A study explored the effectiveness of the oral human papillomavirus (HPV) vaccine IGMKK16E7 in treating cervical intraepithelial neoplasia, showing promising results where some patients experienced a complete histological response.
- Researchers analyzed cervix-exfoliated cell samples from 42 patients to identify biomarkers that could predict the success of the vaccine, focusing on various gene expressions related to immune response.
- The key finding was that lower levels of the biomarker CD86 correlated with a higher likelihood of achieving a complete response to the vaccine, with CD86-low patients demonstrating a significantly increased response rate compared to those with higher CD86 levels.
JNCI Cancer Spectr
October 2023
Article Synopsis
- A clinical trial tested an oral vaccine, IGMKK16E7, derived from lacticaseibacillus to treat patients with HPV-16-positive cervical lesions, aiming to promote local immune responses as opposed to systemic ones.
- Results showed that among high-dose recipients, 31.7% experienced complete regression of lesions compared to only 12.5% in the placebo group, indicating potential effectiveness of the vaccine.
- The study found no significant difference in adverse effects between high-dose and placebo groups, suggesting that IGMKK16E7 is safe while leading to promising immune responses against HPV-16.
