Publications by authors named "Yumika Ito"
Primary lung carcinoma tumors possessing a signet-ring cell carcinoma (SRCC) component at varying proportions are rare, while those primarily composed of an SRCC component are much rarer. Reported here is a case of primary lung adenocarcinoma primarily composed of an SRCC component with a scant acinar component that developed in an 81-year-old male. Approximately 95% of the adenocarcinoma was occupied by an SRCC component that was shown to be diastase-resistant based on positive periodic acid-Schiff staining.
View Article and Find Full Text PDFDevelopment of a myxofibrosarcoma in the breast tissue is extremely rare. Reported here is a case of myxofibrosarcoma found in the left breast tissue of a male in his late fifties. The patient first underwent tumor resection, followed by a left mastectomy with the reconstruction of the vastus lateralis valve.
View Article and Find Full Text PDFBackground: Clear cell sarcoma of soft tissue (CCSST) and clear cell sarcoma-like gastrointestinal tumor (CCSLGT) are malignant mesenchymal tumors that share some pathological features, but they also have several different characteristics. They are well known to express chimeric fusions of Ewing sarcoma breakpoint region 1 (EWSR1) and cAMP response element-binding protein (CREB) family members; namely, EWSR1-activating transcription factor 1 (ATF1) and EWSR1-CREB1. In addition, recent studies have suggested the presence of other fusions.
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- The study analyzed how digital image analysis (IA) of Ki-67 staining can improve prognostic predictions for gastrointestinal stromal tumors (GIST) alongside modified NIH classifications in 92 patients.
- Researchers compared two image analysis methods: whole slide imaging (WSI) and manually captured images (MCI), and identified effective Ki-67 cutoff values that correlate with recurrence-free survival (RFS).
- Findings indicated that Ki-67 quantitation is a strong predictor of prognosis, potentially outperforming traditional NIH classification in determining patient risk levels, making IA a valuable tool for better patient management in GIST cases.
Fluorescence in situ hybridization (FISH) is an essential tool for genetic diagnosis in daily pathological work. Almost full automation of FISH can be achieved with the recently released automated SureFISH platform (Dako Omnis, Agilent Technologies, Santa Clara, CA, USA). Its utility has been reported in HER2 amplification of breast and gastric carcinoma and ALK-rearranged lung cancer.
View Article and Find Full Text PDFBackground: Uterine sarcoma is a rare tumor that is often difficult to classify based on morphological and immunohistochemical analysis alone. Limited access to molecular biological analysis in routine practice would hinder making a definitive diagnosis.
Case Presentation: In this report, we describe a case of a mesenchymal tumor arising from the uterine cervix in a 52-year-old woman.