Publications by authors named "Yumie Tokuhisa"

Article Synopsis
  • Terbinafine (TRF) has been a common treatment for fungal infections for over 20 years, but TRF-resistant strains of fungi like Trichophyton interdigitale and T. rubrum have been found worldwide.
  • This study aimed to investigate TRF-resistant strains in Japanese patients by performing antifungal susceptibility testing on clinical isolates from various skin infections.
  • Out of 210 clinical isolates, five T. rubrum strains showed resistance to TRF, with significant mutations in the squalene epoxidase (SQLE) gene, indicating a connection between genetic changes and TRF resistance.
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A 57-year-old previously healthy woman who works in the fish-processing industry presented with a 1-year history of a slightly pruritic, hyperkeratotic, brownish, erythematous lesion of the left cheek measuring 5 × 5 mm in diameter. Histopathology revealed granuloma formation in the superficial dermal layer by multinucleated giant cells that contained pale-brown septate hyphae. Periodic acid-Schiff stain showed many hyphae and catenate spores within the multinucleated giant cells.

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