Amino acid transporter LAT1 is expressed on cancer cell-derived exosomes with potential as a diagnostic and prognostic biomarker.

L-type amino acid transporter 1 (LAT1) is upregulated in various cancers and contributes to the growth and proliferation of cancer cells. Previous clinicopathological studies have revealed associations between the high expression of LAT1 and the poor prognosis in multiple cancer types. However, in those studies, the expression of LAT1 has been evaluated solely by immunohistochemistry on resected tumors or tissue biopsies.

A Risk Prediction Model for New-Onset Chronic Kidney Disease in the Elderly.

Introduction: Worsening renal function poses a significant health risk to elderly individuals. This study aimed to construct a simple risk prediction model for new-onset chronic kidney disease (CKD) among elderly populations.

Methods: In this retrospective cohort study, 5,416 elderly residents (aged ≥65 years) who underwent physical examinations as part of the National Basic Public Health Service project at least twice between January 2017 and July 2021 were included.

A General Approach for the Synthesis of Cyanoisopropyl Bicyclo[1.1.1]pentane (BCP) Motifs by Energy Transfer Process.

Bicyclo[1.1.1]pentane (BCP) heteroaryls make up an important class of BCP derivatives in drug discovery.

Associations of serum carotenoids with visceral adiposity index and lipid accumulation product: a cross-sectional study based on NHANES 2001-2006.

Background: Visceral adiposity index (VAI) and lipid accumulation product (LAP) are comprehensive indicators to evaluate visceral fat and determine the metabolic health of individuals. Carotenoids are a group of naturally occurring antioxidants associated with several diseases. The purpose of this investigation was to explore the association between serum carotenoid concentration and VAI or LAP.

A 2,2'-bipyridyl calcium complex: synthesis, structure and reactivity studies.

A 2,2'-bipyridyl calcium complex based on a tridentate ligand [CHC(N-2,6-PrCH)CHC(CH)NCHCHN(CH)]Ca(bipy)(THF) (1) was prepared by the reduction of {[CHC(N-2,6-PrCH)CHC(CH)NCHCHN(CH)]CaI(THF)} with potassium graphite in the presence of 2,2'-bipyridine (bipy). Complex 1 is a good Ca(I)synthon, as shown by its reactivity with I, PhCHSSCHPh, PhCHSeSeCHPh and 9-fluorenone, yielding the calcium iodide complex [CHC(N-2,6-PrCH)CHC(CH)NCHCHN(CH)]CaI(bipy) (2), calcium thiolate [CHC(N-2,6-PrCH)CHC(CH)NCHCHN(CH)]Ca(SCHPh)(bipy) (3), calcium selenolate [CHC(N-2,6-PrCH)CHC(CH)NCHCHN(CH)]Ca(SeCHPh)(bipy) (4), and calcium ketyl complex [CHC(N-2,6-PrCH)CHC(CH)NCHCHN(CH)]Ca[O-(9-CH˙)](bipy)·2THF (5·2THF), respectively. In addition, reactions of complex 5 with CS, CHCHCHBr and PhCHBr give the corresponding dimeric bis(thiolate) complex {[SCC(CMe(NAr))C(Me)NCHCHNMe]Ca(DME)} (6), dimeric calcium bromide complex {[(9-CHCHCH-CH-9)-O]CaBr(THF)(bipy)} (7) and {[(9-CHCH-CH-9)-O]CaBr[O-(9-CH)](bipy)} (8).

Azobenzenyl Calcium Complex: Synthesis and Reactivity Studies of a Ca(I) Synthon.

Attempted preparation of a low-valent Ca(I) complex by reduction of Ca iodide precursor [LCaI(THF)] () (L = [CHC(NAr)CHC(CH)NCHCHN(CH)], Ar = 2,6-PrCH), with KC led to isolation of a dinuclear calcium azaallyl complex {[HCC(NAr)CHC(CH)(NCHCHN(CH))]Ca(THF)} (). Alternatively, reaction of with KC in the presence of azobenzene gives an azobenzenyl calcium complex LCa(PhNNPh)(THF) (). The electron paramagnetic resonance and UV-vis spectra of complex suggest that the (PhNNPh) moiety should be regarded as a radical anion.

Pollen-Mimetic Metal-Organic Frameworks with Tunable Spike-Like Nanostructures That Promote Cell Interactions to Improve Antigen-Specific Humoral Immunity.

The exine capsules of pollen particles exhibit a variety of characteristic surface morphologies that promote their cell interactions; their use as antigen carriers for vaccination has been proposed. However, the allergy-causing substances in pollen particles may not all be removed, even by vigorous chemical treatments. To resolve this issue, this work develops systemic approaches for synthesizing pollen-mimetic metal-organic frameworks (MOFs), which comprise aluminum (Al) ions and an organic linker (2-aminoterephthalic acid), with tunable spike-like nanostructures on their surfaces.

Alcohol aggravates ketamine-induced behavioral, morphological and neurochemical alterations in adolescent rats: The involvement of CREB-related pathways.

Currently, an increasing proportion of adolescent ketamine users simultaneously consume alcohol. However, the potential behavioural and neurological alterations induced by such a drug combination and the underlying mechanisms have not been systematically examined. Therefore, in the present study, the behavioural and morphological changes and the underlying mechanisms were studied in adolescent rats after repeated alcohol and/or ketamine treatment.

Alcohol amplifies ketamine-induced apoptosis in primary cultured cortical neurons and PC12 cells through down-regulating CREB-related signaling pathways.

Recreational use of ketamine (KET) has been increasing worldwide. Previous studies have demonstrated that KET induced neurotoxicity; however, few studies have examined how alcohol (ALC) affects KET-induced neurotoxicity. In light of the fact that some KET abusers combine KET with ALC, the present study was aimed to investigate the effects of ALC on KET-induced neurotoxicity and the underlying mechanism in vitro.

Baicalin Attenuates Ketamine-Induced Neurotoxicity in the Developing Rats: Involvement of PI3K/Akt and CREB/BDNF/Bcl-2 Pathways.

Ketamine is widely used as an anesthetic in pediatric clinical practice. However, numerous studies have reported that exposure to ketamine during the developmental period induces neurotoxicity. Here we investigate the neuroprotective effects of baicalin, a natural flavonoid compound, against ketamine-induced apoptotic neurotoxicity in the cortex and hippocampus of the Sprague-Dawley postnatal day 7 (PND7) rat pups.