Publications by authors named "Yumian Lai"

Background: Birth weight is associated with cardiometabolic factors at birth. However, it is unclear when these associations occur in fetal life. We aimed to investigate the associations between fetal growth in different gestational periods and cord blood cardiometabolic factors.

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Purpose: The purpose of this study was to study the impact of epidural analgesia using low-concentration local anesthetic during the entire labor on maternal and neonatal outcomes.

Methods: The authors enrolled 2310 parturient mothers who underwent vaginal delivery at their hospital since January 1, 2019. The parturients were allocated either into the analgesia or into the non-analgesia groups based on whether they received analgesia during the delivery process.

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To test the hypothesis that changes in alpha-7 nicotinic acetylcholine receptor (α7nAChR) expression on macrophages and macrophage polarization participate in cervical remodeling during normal pregnancy, pregnant rats from gestational days (GDs) 14, 16, 18, 20, and 22 were used in the present study. The expression of α7nAChR on macrophages and the numbers of M1 and M2 macrophages were detected by double immunofluorescence staining. The levels of α7nAChR and collagens were detected by western blotting.

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To study the perinatal outcomes in the women who's the different changes of an increased fetal nuchal translucency thickness. Since 2013-2016, the pregnant women whose initial measurement of fetal nuchal translucency (NT) ≥ 3.5 mm would be invited to scan the NT again after a week.

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Preterm birth (PTB, <37 weeks) is the leading cause of death in children <5 years of age. Early risk prediction for PTB would enable early monitoring and intervention. However, such prediction models have been rarely reported, especially in low- and middle-income areas.

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Article Synopsis
  • - The study investigated the links between specific genetic variations in the insulin-like growth factor (IGF) pathway, particularly IGF1 rs972936 and IGF1 receptor rs2229765, and the risk of spontaneous preterm birth (SPTB) among Chinese women.
  • - Results showed that certain genotypes of IGF1 rs972936 (GA and GA/AA) are associated with an increased risk of SPTB, while specific genotypes of IGF1R rs2229765 (GA and GA/AA) may lower the risk compared to others.
  • - The findings also indicated that the risk factors related to these genotypes interacted with maternal health factors, like gestational diabetes and pre-pregnancy
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